{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:39:06Z","timestamp":1791121146940,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,2,1]]},"abstract":"<jats:p>T lymphocyte infiltration is a prominent feature of the skin inflammation associated with infections by toxin (superantigen)-secreting Staphylococcus aureus or Streptococcus bacteria. The cutaneous lymphocyte-associated antigen (CLA) has been hypothesized to be a homing receptor (HR) involved in selective migration of memory\/effector T cells to the skin. Since the expression of this putative skin-selective HR is known to be under strict microenvironmental control, we sought to determine the effect of staphylococcal and streptococcal toxins on T cell expression of CLA. After in vitro stimulation of peripheral blood mononuclear cells with staphylococcal enterotoxin B, toxic shock syndrome toxin-1, and streptococcal pyrogenic exotoxins A and C, there was a significant increase in the numbers of CLA+ T cell blasts (p &amp;lt; 0.01), but not blasts bearing the mucosa-associated adhesion molecule alpha e beta 7-integrin, compared with T cells stimulated with phytohemaglutinin (PHA) or anti-CD3. Bacterial toxins were also found to specifically induce interleukin (IL) 12 production. More importantly, induction of toxin-induced CLA expression was blocked by anti-IL-12, and the addition of IL-12 to PHA-stimulated T cells induced CLA, but not alpha e beta 7-integrin, expression. These data suggest that bacterial toxins induce the expansion of skin-homing CLA+ T cells in an IL-12-dependent manner, and thus may contribute to the development of skin rashes in superantigen-mediated diseases.<\/jats:p>","DOI":"10.1084\/jem.181.2.747","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"747-753","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":246,"title":["Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production."],"prefix":"10.1084","volume":"181","author":[{"given":"D Y","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Gately","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Trumble","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Ferguson-Darnell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P M","family":"Schlievert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L J","family":"Picker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1995,2,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/181\/2\/747\/1676832\/747.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/181\/2\/747\/1676832\/747.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T06:39:56Z","timestamp":1690267196000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/181\/2\/747\/50677\/Bacterial-superantigens-induce-T-cell-expression"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,2,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.181.2.747","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2,1]]}}}