{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:51:21Z","timestamp":1790250681392,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,3,1]]},"abstract":"<jats:p>Virus infections of the lung are thought to predispose individuals to asthma, a disease characterized by eosinophil infiltration of the airways. CD8+ T cells are an important part of the host response to virus infection, however, they have no reported role in eosinophil recruitment. We developed a mouse model of virus peptide-stimulated CD8+ T cell immune responses in the lung. We found that bystander CD4+ T helper cell type 2 immune responses to ovalbumin switched the virus peptide-specific CD8+ T cells in the lung to interleukin (IL) 5 production. Furthermore, when such IL-5-producing CD8 T cells were challenged via the airways with virus peptide, a significant eosinophil infiltration was induced. In vitro studies indicated that IL-4 could switch the virus-specific CD8+ T cells to IL-5 production. These results could explain the link between virus infection and acute exacerbation of asthma and, perhaps more importantly, they indicate an IL-4-dependent mechanism that would impair CD8+ T cell responses and delay viral clearance from the host.<\/jats:p>","DOI":"10.1084\/jem.181.3.1229","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1229-1233","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":202,"title":["Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia."],"prefix":"10.1084","volume":"181","author":[{"given":"A J","family":"Coyle","sequence":"first","affiliation":[{"name":"Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Erard","sequence":"additional","affiliation":[{"name":"Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Walti","sequence":"additional","affiliation":[{"name":"Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Pircher","sequence":"additional","affiliation":[{"name":"Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Le Gros","sequence":"additional","affiliation":[{"name":"Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/181\/3\/1229\/1677718\/1229.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/181\/3\/1229\/1677718\/1229.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T06:58:53Z","timestamp":1690268333000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/181\/3\/1229\/50844\/Virus-specific-CD8-cells-can-switch-to-interleukin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.181.3.1229","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3,1]]}}}