{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:45:54Z","timestamp":1770738354574,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,5,1]]},"abstract":"<jats:p>The cutaneous lymphocyte-associated antigen (CLA) is the major T cell ligand for the vascular adhesion molecule E-selectin, and it has been proposed to be involved in the selective targeting of memory T cells reactive with skin-associated Ag to cutaneous inflammatory sites. To further investigate the relation of CLA and cutaneous T cell responses, we analyzed the CLA phenotype of circulating memory T cells in patients with allergic contact dermatitis and atopic dermatitis (AD) alone vs in patients manifesting bronchopulmonary atopy (asthma with or without AD) and nonallergic individuals. Significant T cell proliferative responses to Ni, a contact allergen, and to the house dust mite (HDM), an allergen to which sensitization is often observed in AD and\/or asthma, was noted only in allergic and atopic individuals, respectively. When the minor circulating CLA+CD3+CD45RO+ subset was separated from the major CLA-CD3+CD45RO+ subpopulation in Ni-sensitive subjects, the Ni-dependent memory T cell response was largely confined to the CLA+ subset. A similar restriction of the T cell proliferative response to the CLA+ memory subset was observed for HDM in patients with AD alone. In HDM-sensitive patients with asthma with or without AD, however, the CLA- subset exhibited a strong antigen-dependent proliferation, in contrast to patients with AD alone, whose CLA- subset proliferated very weakly to HDM. In asthma with or without AD, the HDM-dependent proliferation slightly predominated in the CLA- when compared to the CLA+ subset. The functional linkage between CLA expression and disease-associated T cell effector function in AD was also demonstrated by the finding that the circulating CLA+ T cell subset in AD patients, but not nonatopic controls, selectively showed both evidence of prior activation (human histocompatibility antigen-DR expression) and spontaneous production of interleukin 4 but not interferon-gamma. Taken together, these observations demonstrate the correlation of CLA expression on circulating memory T cells and disease-associated memory T cell responses in cutaneous hypersensitivity, and they suggest the existence of mechanisms capable of sorting particular T cell Ag specificities and lymphokine patterns into homing receptor-defined memory subsets.<\/jats:p>","DOI":"10.1084\/jem.181.5.1935","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1935-1940","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":226,"title":["Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen."],"prefix":"10.1084","volume":"181","author":[{"given":"L F","family":"Santamaria Babi","sequence":"first","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research, Davos."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L J","family":"Picker","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research, Davos."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M T","family":"Perez Soler","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research, Davos."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Drzimalla","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research, Davos."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Flohr","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research, Davos."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Blaser","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research, Davos."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hauser","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research, Davos."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1995,5,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/181\/5\/1935\/1676804\/1935.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/181\/5\/1935\/1676804\/1935.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T06:39:11Z","timestamp":1690267151000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/181\/5\/1935\/25317\/Circulating-allergen-reactive-T-cells-from"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.181.5.1935","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,1]]}}}