{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:27:58Z","timestamp":1792661278795,"version":"4.5.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,1,1]]},"abstract":"<jats:p>Cytotoxic T lymphocytes (CTLs) are a critical component of the immune response to tumors. Tumor-derived peptide antigens targeted by CTLs are being defined for several human tumors and are potential immunogens for the induction of specific antitumor immunity. Dendritic cells (DC) are potent antigen-presenting cells (APCs) capable of priming CTL responses in vivo. Here we show that major histocompatibility complex class I-presented peptide antigen pulsed onto dendritic APCs induces protective immunity to lethal challenge by a tumor transfected with the antigen gene. The immunity is antigen specific, requiring expression of the antigen gene by the tumor target, and is eliminated by in vivo depletion of CD8+ T cells. Furthermore, mice that have rejected the transfected tumor are protected from subsequent challenge with the untransfected parent tumor. These results suggest that immunization strategies using antigen-pulsed DC may be useful for inducing tumor-specific immune responses.<\/jats:p>","DOI":"10.1084\/jem.183.1.283","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"283-287","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":522,"title":["Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity."],"prefix":"10.1084","volume":"183","author":[{"given":"C M","family":"Celluzzi","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Mayordomo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W J","family":"Storkus","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Lotze","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"L D","family":"Falo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1996,1,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/1\/283\/1678576\/283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/1\/283\/1678576\/283.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:14:21Z","timestamp":1690269261000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/183\/1\/283\/58321\/Peptide-pulsed-dendritic-cells-induce-antigen"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.183.1.283","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1,1]]}}}