{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:31:56Z","timestamp":1787563916007,"version":"build-2736575974"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,3,1]]},"abstract":"<jats:p>Recent studies have shown that only a subset of major histocompatibility complex (MHC) class II molecules are able to present bacterial superantigens to T cells, leading to the suggestion that class-II associated peptides may influence superantigen presentation. Here, we have assessed the potential role of peptides on superantigen presentation by (a) analyzing the ability of superantigens to block peptide-specific T cell responses and (b) analyzing the ability of individual peptides to promote superantigen presentation on I-Ab-expressing T2 cells that have a quantitative defect in antigen processing. A series of peptides is described that specifically promote either toxic shock syndrome toxin (TSST) 1 or staphylococcal enterotoxin A (SEA) presentation. Whereas some peptides promoted the presentation of TSST-1 (almost 5,000-fold in the case of one peptide), other peptides promoted the presentation of SEA. These data demonstrate that MHC class II-associated peptides differentially influence the presentation of bacterial superantigens to T cells.<\/jats:p>","DOI":"10.1084\/jem.183.3.1083","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T03:56:10Z","timestamp":1088049370000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Major histocompatibility complex class II-associated peptides control the presentation of bacterial superantigens to T cells."],"prefix":"10.1084","volume":"183","author":[{"given":"R","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G A","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Surman","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Blackman","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D L","family":"Woodland","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1996,3,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/3\/1083\/1678125\/1083.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/3\/1083\/1678125\/1083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T03:05:11Z","timestamp":1690254311000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/183\/3\/1083\/47867\/Major-histocompatibility-complex-class-II"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.183.3.1083","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3,1]]}}}