{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:38:55Z","timestamp":1790519935295,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,4,1]]},"abstract":"<jats:p>Naive and memory B cells were isolated from human tonsils and examined for expression of APO-1\/Fas and for their sensitivity to the APO-1-dependent apoptosis. APO-1 was found to be constitutively expressed on memory but not on naive B cells. The susceptibility of both cell types to the APO-1 apoptotic pathway was acquired upon CD40 triggering and was correlated with increased expression of the APO-1 receptor. Both naive and memory B cells were protected from the APO-1-mediated death signal after dual ligation of the Ag receptor adn CD40. Our findings suggest that the APO-1 pathway controls the specificity of B cell responses to T-dependent Ags and that occupancy of the Ag receptor dictates the outcome of APO-1-ligation on B cell survival.<\/jats:p>","DOI":"10.1084\/jem.183.4.1377","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1377-1388","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":82,"title":["Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1\/Fas-mediated apoptosis."],"prefix":"10.1084","volume":"183","author":[{"given":"C","family":"Lagresle","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit 404, \"Immunit\u00e9 et Vaccination,\" Institut Pasteur de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Mondi\u00e8re","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit 404, \"Immunit\u00e9 et Vaccination,\" Institut Pasteur de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bella","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit 404, \"Immunit\u00e9 et Vaccination,\" Institut Pasteur de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Krammer","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit 404, \"Immunit\u00e9 et Vaccination,\" Institut Pasteur de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Defrance","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit 404, \"Immunit\u00e9 et Vaccination,\" Institut Pasteur de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1996,4,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/4\/1377\/1678494\/1377.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/4\/1377\/1678494\/1377.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:13:34Z","timestamp":1690269214000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/183\/4\/1377\/58410\/Concurrent-engagement-of-CD40-and-the-antigen"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.183.4.1377","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4,1]]}}}