{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:48:14Z","timestamp":1792658894569,"version":"4.5.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,4,1]]},"abstract":"<jats:p>Dendritic cells isolated from thymus and tonsil were tested for susceptibility to HIV-1 strains that are tropic for macrophages or for T cell lines. DCs were purified by cell sorting and before infection expressed high levels of CD4 and HLA-DR and lacked markers for T, B, NK cells, or macrophages. Viral entry and reverse transcription was found after pulsing with strains of HIV-1 that could infect macrophages. During the first 36 h the PCR signals for gag sequences increased in DCs and macrophages. In contrast little if any viral DNA was found after pulsing macrophages or DCs with HIV-1 that was able to infect T cell lines. DCs pulsed with HIV-1 were able to transmit infection to responding T cells during an allogeneic or superantigen response. Selection for virus able to infect lymphoid DCs and other DCs expressing CD4 and its transfer to T cells during subsequent immune responses may provide a mechanism for the observed predominance of macrophage-tropic HIV-1 after in vivo transmission.<\/jats:p>","DOI":"10.1084\/jem.183.4.1851","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1851-1856","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["The interaction of macrophage and non-macrophage tropic isolates of HIV-1 with thymic and tonsillar dendritic cells in vitro."],"prefix":"10.1084","volume":"183","author":[{"given":"P U","family":"Cameron","sequence":"first","affiliation":[{"name":"AIDS Pathogenesis Unit, Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Lowe","sequence":"additional","affiliation":[{"name":"AIDS Pathogenesis Unit, Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Sotzik","sequence":"additional","affiliation":[{"name":"AIDS Pathogenesis Unit, Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A F","family":"Coughlan","sequence":"additional","affiliation":[{"name":"AIDS Pathogenesis Unit, Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Crowe","sequence":"additional","affiliation":[{"name":"AIDS Pathogenesis Unit, Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Shortman","sequence":"additional","affiliation":[{"name":"AIDS Pathogenesis Unit, Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1996,4,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/4\/1851\/1678654\/1851.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/4\/1851\/1678654\/1851.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:15:15Z","timestamp":1690269315000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/183\/4\/1851\/58377\/The-interaction-of-macrophage-and-non-macrophage"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.183.4.1851","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4,1]]}}}