{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:41:51Z","timestamp":1791052911154,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,5,1]]},"abstract":"<jats:p>The ligand for CD40 (CD40L) is expressed on the surface of activated CD4+ T cells and its role in T-B cell collaborations and thymus-dependent humoral immunity is well established. Recently, by generating CD40L-knockout mice, we have confirmed its previously described role in humoral immunity and defined another important function of this molecule in the in vivo clonal expansion of antigen-specific CD4+ T cells. Here, we investigated the potential in vivo role of CD40L in antiviral immunity by examining the immune response mounted by CD40L-deficient mice following infection with lymphocytic choriomeningitis virus (LCMV), Pichinde virus, or vesicular stomatitis virus. Humoral immune responses of CD40L-deficient mice to these viruses were severely compromised, although moderate titres of antiviral IgM and some IgG2a were produced by virus-infected CD40L-deficient mice by a CD4+ T cell-independent mechanism. By contrast, CD40L-deficient mice made strong primary CTL responses to all three viruses. Interestingly however, although memory CTL activity was detectable in CD40L-deficient mice two months after infection with LCMV, the memory CTL response was much less efficient than in wild-type mice. Together, the results show that CD40-CD40L interactions are required for strong antiviral humoral immune responses, and reveal a novel role for CD40L in the establishment and\/or maintenance of CD8+ CTL memory.<\/jats:p>","DOI":"10.1084\/jem.183.5.2129","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"2129-2142","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":203,"title":["CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response."],"prefix":"10.1084","volume":"183","author":[{"given":"P","family":"Borrow","sequence":"first","affiliation":[{"name":"Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tishon","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I S","family":"Grewal","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M B","family":"Oldstone","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Flavell","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1996,5,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/5\/2129\/1678952\/2129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/5\/2129\/1678952\/2129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:18:51Z","timestamp":1690269531000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/183\/5\/2129\/57647\/CD40L-deficient-mice-show-deficits-in-antiviral"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.183.5.2129","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5,1]]}}}