{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:36:28Z","timestamp":1775151388829,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,5,1]]},"abstract":"<jats:p>Herpesviral DNA fragments isolated from AIDS-associated Kaposi's sarcoma (KS) tissue (KSHV-DNA) share homology with two lymphotropic oncogenic gamma-herpesviruses, Epstein-Barr virus and Herpesvirus saimiri, and are present in the lesions of more than 95% of HIV and non-HIV-associated forms of KS, AIDS-related body cavity-based lymphomas, and AIDS-related multicentric Castleman's disease. Here we show that BC-1, a KSHV-DNA-positive, body cavity-based lymphoma cell line, produces infective herpesviral particles carrying a linear 270-kb genome that specifically transmits KSHV-DNA to CD19+ B cells. Transmission of KSHV-DNA is dependent upon a biologically active, replicating virus, since it is blocked by UV irradiation and foscarnet, an inhibitor of viral DNA-polymerase. This study represents the first isolation and transmission of the human herpesvirus-8\/KS-associated herpesvirus.<\/jats:p>","DOI":"10.1084\/jem.183.5.2385","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"2385-2390","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":202,"title":["Human herpesvirus-8\/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells."],"prefix":"10.1084","volume":"183","author":[{"given":"E A","family":"Mesri","sequence":"first","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York 10021, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Cesarman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York 10021, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Arvanitakis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York 10021, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rafii","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York 10021, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York 10021, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D N","family":"Posnett","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York 10021, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Knowles","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York 10021, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"Asch","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cornell University Medical College, New York 10021, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1996,5,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/5\/2385\/1679027\/2385.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/183\/5\/2385\/1679027\/2385.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:20:11Z","timestamp":1690269611000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/183\/5\/2385\/57672\/Human-herpesvirus-8-Kaposi-s-sarcoma-associated"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.183.5.2385","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5,1]]}}}