{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:49:12Z","timestamp":1791114552473,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,9,1]]},"abstract":"<jats:p>A unique experimental model has been developed for dissecting the integrity of CD8+ T cell-mediated immunity to a persistent gammaherpesvirus under conditions of CD4+ T cell deficiency. Respiratory challenge of major histocompatibility complex class II -\/- and +\/+ C57BL\/6J mice with the murine gammaherpesvirus 68 (MHV-68) leads to productive infection of both lung and adrenal epithelial cells. Virus titers peak within 5-10 d, and are no longer detected after day 15. Persistent, latent infection is established concurrently in splenic and lymph node B cells, with higher numbers of MHV-68+ lymphocytes being found in all lymphoid sites analyzed from the +\/+ mice concurrent with the massive, but transient splenomegaly that occurred only in this group. From day 17, however, the numbers of infected B lymphocytes were consistently higher in the -\/- group, while the frequency of this population diminished progressively in the +\/+ controls. Infectious MHV-68 was again detected in the respiratory tract and the adrenals of the -\/- (but not the +\/+) mice from day 22 after infection. The titers in these sites rose progressively, with the majority of the -\/- mice dying between days 120 and 133. Even so, some CD8+ effectors were still functioning as late as 100 d after infection. Depletion of CD8+ T cells at this stage led to higher virus titers in the -\/- lung, and to the development of wasting in some of the -\/- mice. Elimination of the CD8+ T cells from the +\/+ group (day 80) increased the numbers of MHV-68+ cells in the spleen, but did not reactivate the infection in the respiratory tract. The results are consistent with the interpretation that CD8+ T cell-mediated control of this persistent gammaherpesvirus is progressively lost in the absence of the CD4+ T cell subset. This parallels what may be happening in AIDS patients who develop Kaposi's sarcoma and various Epstein Barr virus associated disease processes.<\/jats:p>","DOI":"10.1084\/jem.184.3.863","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"863-871","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":386,"title":["Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells."],"prefix":"10.1084","volume":"184","author":[{"given":"R D","family":"Cardin","sequence":"first","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J W","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S R","family":"Sarawar","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Doherty","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1996,9,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/184\/3\/863\/1679109\/863.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/184\/3\/863\/1679109\/863.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:21:27Z","timestamp":1690269687000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/184\/3\/863\/50957\/Progressive-loss-of-CD8-T-cell-mediated-control-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.184.3.863","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,9,1]]}}}