{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:45:44Z","timestamp":1770738344600,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:p>CD4+ and CD8+ alpha\/beta+ T cells of the T helper cell (Th)2 phenotype produce the cytokines IL-4, IL-5, and IL-13 that promote IgE production and eosinophilic inflammation. IL-4 may play an important role in mediating the differentiation of antigenically naive alpha\/beta+ T cells into Th2 cells. Murine NK1.1+ (CD4+ or CD4-CD8-) alpha\/beta+ T cells comprise a beta 2-microglobulin (beta 2m)-dependent cell population that rapidly produces IL-4 after cell activation in vitro and in vivo and has been proposed as a source of IL-4 for Th2 cell differentiation. alpha\/beta+ CD8+ T cells, most of which require beta 2m for their development, have also been proposed as positive regulators of allergen-induced Th2 responses. We tested whether beta 2m-dependent T cells were essential for Th2 cell-mediated allergic reactions by treating wild-type, beta 2m-deficient (beta 2m -\/-), and IL-4-deficient (IL-4 -\/-) mice of the C57BL\/6 genetic background with ovalbumin (OVA), using a protocol that induces robust allergic pulmonary disease in wild-type mice. OVA-treated beta 2m -\/- mice had circulating levels of total and OVA-specific IgE, pulmonary eosinophilia, and expression of IL-4, IL-5, and IL-13 mRNA in bronchial lymph node tissue similar to that of OVA-treated wild-type mice. In contrast, these responses in OVA-treated IL-4 -\/- mice were all either undetectable or markedly reduced compared with wild-type mice, confirming that IL-4 was required in this allergic model. These results indicate that the NK1.1+ alpha\/beta+ T cell population, as well as other beta 2m-dependent populations, such as most peripheral alpha\/beta+ CD8+ T cells, are dispensable for the Th2 pulmonary response to protein allergens.<\/jats:p>","DOI":"10.1084\/jem.184.4.1507","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1507-1512","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":70,"title":["Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses."],"prefix":"10.1084","volume":"184","author":[{"given":"Y","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle 98195, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K H","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle 98195, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D B","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle 98195, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1996,10,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/184\/4\/1507\/1679364\/1507.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/184\/4\/1507\/1679364\/1507.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:26:17Z","timestamp":1690269977000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/184\/4\/1507\/51142\/Beta-2-microglobulin-dependent-T-cells-are"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.184.4.1507","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10,1]]}}}