{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:18:13Z","timestamp":1791274693045,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:p>A number of distinct functional abnormalities have been observed in B cells derived from p50\/ NF-kappa B or c-rel knockout mice. RelB, another member of the NF-kappa B\/Rel family of transcription factors, is expressed during the latter stages of B cell maturation and can bind to regulatory sites within the Ig heavy chain locus. Therefore, we tested the ability of B cells from relB knockout mice (relB-\/-) to proliferate, undergo maturation to IgM secretion, and switch to the expression of downstream Ig isotypes in response to distinct activators including LPS, anti-CD40 mAb or CD40 ligand, and\/or dextran anti-IgD antibodies in combination with various cytokines, including IL-4, IL-5, IFN-gamma, and TGF-beta. B cells lacking RelB showed up to 4-fold reductions in DNA synthesis in response to LPS, CD40, and membrane Ig-dependent activation relative to controls. However, relB-\/- B cells were comparable to control B cells in their ability to undergo maturation to IgM secretion and switch to the expression of IgG3, IgG1, IgG2b, IgG2a, IgE, and\/or IgA under all activation conditions tested. Thus, RelB, like c-Rel and p50\/NF-kappa B, plays a role in B cell proliferation. However, in contrast to c-Rel and p50\/ NF-kappa B, it is not critically involved in maturation to Ig secretion or expression of Ig isotypes.<\/jats:p>","DOI":"10.1084\/jem.184.4.1537","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1537-1541","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":81,"title":["B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching."],"prefix":"10.1084","volume":"184","author":[{"given":"C M","family":"Snapper","sequence":"first","affiliation":[{"name":"Department of Pathology, Uniformed Services, Bethesda, Maryland 20814, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F R","family":"Rosas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uniformed Services, Bethesda, Maryland 20814, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Zelazowski","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uniformed Services, Bethesda, Maryland 20814, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Moorman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uniformed Services, Bethesda, Maryland 20814, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M R","family":"Kehry","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uniformed Services, Bethesda, Maryland 20814, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bravo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uniformed Services, Bethesda, Maryland 20814, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Weih","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uniformed Services, Bethesda, Maryland 20814, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1996,10,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/184\/4\/1537\/1679212\/1537.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/184\/4\/1537\/1679212\/1537.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:22:36Z","timestamp":1690269756000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/184\/4\/1537\/51154\/B-cells-lacking-RelB-are-defective-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,10,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.184.4.1537","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10,1]]}}}