{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:14:42Z","timestamp":1791126882738,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,11,1]]},"abstract":"<jats:p>Rheumatoid arthritis is a multistep disorder associated with autoimmune features of yet unknown etiology. Implication of viruses such as Epstein-Barr virus (EBV) in rheumatoid arthritis pathogenesis has been suspected on the basis of several indirect observations, but thus far, a direct link between EBV and rheumatoid arthritis has not been provided. Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators (BZLF1 and BMLF1) in a major histocompatibility complex-restricted fashion. Responses to these EBV antigens by synovial lymphocytes from several other chronic rheumatoid arthritis patients were readily detectable. Thus these results suggest a direct contribution of EBV to chronic rheumatoid arthritis pathogenesis. They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors, which might be central in the control of virus reactivation.<\/jats:p>","DOI":"10.1084\/jem.184.5.1791","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1791-1800","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":119,"title":["T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis."],"prefix":"10.1084","volume":"184","author":[{"given":"E","family":"Scotet","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"David-Ameline","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Peyrat","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Moreau-Aubry","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Pinczon","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lim","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Even","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Semana","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Berthelot","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Breathnach","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bonneville","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Houssaint","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U211, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1996,11,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/184\/5\/1791\/1679188\/1791.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/184\/5\/1791\/1679188\/1791.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:22:19Z","timestamp":1690269739000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/184\/5\/1791\/51082\/T-cell-response-to-Epstein-Barr-virus"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.184.5.1791","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11,1]]}}}