{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:20:22Z","timestamp":1793089222937,"version":"4.5.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,11,1]]},"abstract":"<jats:p>The T lymphocytes mediating autoimmune destruction of pancreatic beta cells in the nonobese diabetic (NOD) mouse model of insulin-dependent diabetes mellitus (IDDM) may be generated due to functional defects in hematopoietically derived antigen-presenting cells (APC). However, it has not been clear which particular subpopulations of APC (B lymphocytes, macrophages, and dendritic cells) contribute to the development and activation of diabetogenic T cells in NOD mice. In the current study we utilized a functionally inactivated immunoglobulin (Ig) mu allele (Ig mu null) to generate a \"speed congenic\" stock of B lymphocyte-deficient NOD mice that are fixed for linkage markers delineating previously identified diabetes susceptibility (Idd) genes. These B lymphocyte NOD.Ig mu null mice had normal numbers of T cells but were free of overt IDDM and insulitis resistant, while the frequency of disease in the B lymphocyte intact segregants was equivalent to that of standard NOD mice in our colony. Thus, B lymphocytes play a heretofore unrecognized role that is essential for the initial development and\/or activation of beta cell autoreactive T cells in NOD mice.<\/jats:p>","DOI":"10.1084\/jem.184.5.2049","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"2049-2053","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":428,"title":["B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new \"speed congenic\" stock of NOD.Ig mu null mice."],"prefix":"10.1084","volume":"184","author":[{"given":"D V","family":"Serreze","sequence":"first","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H D","family":"Chapman","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Varnum","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Hanson","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Reifsnyder","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S D","family":"Richard","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S A","family":"Fleming","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E H","family":"Leiter","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L D","family":"Shultz","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1996,11,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/184\/5\/2049\/1679513\/2049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/184\/5\/2049\/1679513\/2049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:28:16Z","timestamp":1690270096000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/184\/5\/2049\/51098\/B-lymphocytes-are-essential-for-the-initiation-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.184.5.2049","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11,1]]}}}