{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:36:58Z","timestamp":1770698218363,"version":"3.49.0"},"reference-count":40,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,5,19]]},"abstract":"<jats:p>Recent evidence indicates that chronic autoimmune disease can result from breakdown of regulation and subsequent activation of self-reactive T cells. In many murine autoimmune disease systems and in the Lewis rat, antigen-specific T cells utilizing the T cell receptor (TCR) V\u03b28.2 gene segment play a major role. In the myelin basic protein\u2013induced experimental autoimmune encephalomyelitis (EAE) model in H-2u mice, we had shown that T cells recognizing a peptide determinant within the framework 3 region of the V\u03b28.2 chain have a critical role in influencing the course of the disease. Here, we report experiments in another disease system, collagen II (CII)\u2013induced arthritis (CIA) in DBA\/1LacJ (H-2q) mice, indicating a remarkably parallel control circuit to that found for EAE. A critical role is played by CII-specific V\u03b28.2bearing T cells in the CIA system, which we have confirmed. Animals treated with the superantigen SEB before CII administration are significantly protected from CIA. Next, we tested the ability of peptides encompassing the entire V\u03b28.2 chain to induce proliferative responses. Only TCR peptide B5 (amino acids 76\u2013101), a regulatory peptide in EAE, induced proliferation. B5 was then used to vaccinate DBA\/1LacJ mice and was shown to reduce greatly the severity and incidence of CIA as measured by joint inflammation or histology. Furthermore, similar protection was found when B5 was administered after CII immunization. It was shown that there is physiological induction of a proliferative response to B5 during CIA and that the determinant within B5 is produced from a single chain TCR construct containing the entire V\u03b28.2 chain. Finally, the regulation of CIA is discussed in the context of other experimental autoimmune diseases, especially EAE, with emphasis on what appear to be strikingly common mechanisms.<\/jats:p>","DOI":"10.1084\/jem.185.10.1725","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1725-1733","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Regulatory T Cells Specific for the Same Framework 3 Region of the V\u03b28.2 Chain Are Involved in the Control of Collagen II\u2013induced Arthritis and Experimental Autoimmune Encephalomyelitis"],"prefix":"10.1084","volume":"185","author":[{"given":"Vipin","family":"Kumar","sequence":"first","affiliation":[{"name":"From the Department of Microbiology and Molecular Genetics, University of California, Los Angeles, California 90095-1489"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatema","family":"Aziz","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Molecular Genetics, University of California, Los Angeles, California 90095-1489"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Sercarz","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Molecular Genetics, University of California, Los Angeles, California 90095-1489"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Miller","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Molecular Genetics, University of California, Los Angeles, California 90095-1489"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1997,5,19]]},"reference":[{"key":"2023072506545038700_B1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0167-5699(89)90174-6","article-title":"The V-region hypothesis: evidence from autoimmune encephalomyelitis","volume":"10","author":"Heber-Katz","year":"1989","journal-title":"Immunol Today"},{"key":"2023072506545038700_B2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(88)90558-2","article-title":"Limited heterogeneity of T cell receptors from lymphocyte mediating autoimmune encephalomyelitis allows specific immune intervention","volume":"54","author":"Acha-Orbea","year":"1988","journal-title":"Cell"},{"key":"2023072506545038700_B3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0092-8674(88)90079-7","article-title":"Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy","volume":"54","author":"Urban","year":"1988","journal-title":"Cell"},{"key":"2023072506545038700_B4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/08830189309051212","article-title":"T cell regulatory circuitry: antigen-specific and TCR\u2013idiopeptide-specific T cell interactions in EAE","volume":"9","author":"Kumar","year":"1993","journal-title":"Int Rev Immunol"},{"key":"2023072506545038700_B5","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1084\/jem.178.3.909","article-title":"The involvement of T cell receptor peptide-specific regulatory CD4+T cells in recovery from antigen-induced autoimmune disease","volume":"178","author":"Kumar","year":"1993","journal-title":"J Exp Med"},{"key":"2023072506545038700_B6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/(SICI)1097-4547(19960815)45:4<334::AID-JNR2>3.0.CO;2-A","article-title":"Dysregulation of potentially pathogenic self reactivity is crucial for the manifestation of clinical autoimmunity","volume":"45","author":"Kumar","year":"1996","journal-title":"J Neurosci Res"},{"key":"2023072506545038700_B7","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1084\/jem.184.5.1609","article-title":"Inactivation of CD4 regulatory T cells results in chronic autoimmunity","volume":"184","author":"Kumar","year":"1996","journal-title":"J Exp Med"},{"key":"2023072506545038700_B8","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1084\/jem.146.3.857","article-title":"Autoimmunity to type II collagen: an experimental model of arthritis","volume":"146","author":"Trentham","year":"1977","journal-title":"J Exp Med"},{"key":"2023072506545038700_B9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev.iy.02.040184.001215","article-title":"Collagen autoimmune arthritis","volume":"2","author":"Stuart","year":"1984","journal-title":"Annu Rev Immunol"},{"key":"2023072506545038700_B10","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/283666a0","article-title":"Immunization against heterologous type II collagen induces arthritis in mice","volume":"283","author":"Courtenay","year":"1980","journal-title":"Nature (Lond)"},{"key":"2023072506545038700_B11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/art.1780290114","article-title":"Homologous type II collagen induces chronic and progressive arthritis in mice","volume":"29","author":"Holmdahl","year":"1986","journal-title":"Arthritis Rheum"},{"key":"2023072506545038700_B12","first-page":"305","article-title":"Immunogenetics of type II collagen autoimmunity and susceptibility to collagen arthritis","volume":"65","author":"Holmdahl","year":"1988","journal-title":"Immunology"},{"key":"2023072506545038700_B13","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1084\/jem.162.3.1105","article-title":"Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4","volume":"162","author":"Ranges","year":"1985","journal-title":"J Exp Med"},{"key":"2023072506545038700_B14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0008-8749(89)90396-1","article-title":"Experimental synovitis induced by collagen-specific T cell lines","volume":"118","author":"Brahn","year":"1989","journal-title":"Cell Immunol"},{"key":"2023072506545038700_B15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4049\/jimmunol.140.1.78","article-title":"Isolation of T cell line capable of protecting mice against collagen-induced arthritis","volume":"140","author":"Kakimoto","year":"1988","journal-title":"J Immunol"},{"key":"2023072506545038700_B16","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1073\/pnas.84.13.4577","article-title":"Therapeutic vaccination against adjuvant arthritis using autoimmune T cells treated with hydrostatic pressure","volume":"84","author":"Lider","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072506545038700_B17","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1084\/jem.167.3.832","article-title":"Possible role of V\u03b2 T cell receptor genes in collagen induced arthritis in mice","volume":"167","author":"Banerjee","year":"1988","journal-title":"J Exp Med"},{"key":"2023072506545038700_B18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0896-8411(90)90135-F","article-title":"T-cell receptor V\u03b2genes repertoire in mice possible role in resistance and susceptibility to type II collagen-induced arthritis","volume":"3","author":"Haqqi","year":"1990","journal-title":"J Autoimmunity"},{"key":"2023072506545038700_B19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1749-6632.1995.tb44517.x","article-title":"Limited heterogeneity in T cell receptor V beta chain gene expression in arthritic joints of BUB\/BnJ (H-2q) mice, a T cell receptor V\u03b2astrain","volume":"756","author":"Haqqi","year":"1995","journal-title":"Ann NY Acad Sci"},{"key":"2023072506545038700_B20","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1073\/pnas.89.4.1253","article-title":"Restricted heterogeneity in T-cell antigen receptor V\u03b2 gene usage in the lymph nodes and arthritic joints of mice","volume":"89","author":"Haqqi","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072506545038700_B21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.177.2.387","article-title":"Characterization of the T cell receptor repertoire causing collagen arthritis in mice","volume":"177","author":"Osman","year":"1993","journal-title":"J Exp Med"},{"key":"2023072506545038700_B22","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1002\/eji.1830211202","article-title":"Therapy against murine collagen-induced arthritis with T cell receptor V\u03b2-specific antibodies","volume":"21","author":"Chiocchia","year":"1991","journal-title":"Eur J Immunol"},{"key":"2023072506545038700_B23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/rheumatology\/32.1.26","article-title":"Prevention of collagen induced arthritis in mice by deletion of T cell receptor V\u03b28 bearing T cells with monoclonal antibodies","volume":"32","author":"Moder","year":"1993","journal-title":"Br J Rheumat"},{"key":"2023072506545038700_B24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/332035a0","article-title":"Self tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex","volume":"332","author":"Kappler","year":"1988","journal-title":"Nature (Lond)"},{"key":"2023072506545038700_B25","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/0092-8674(90)90420-J","article-title":"Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity","volume":"63","author":"Webb","year":"1990","journal-title":"Cell"},{"key":"2023072506545038700_B26","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0022-2836(92)90455-S","article-title":"Secretion of T cell receptor fragments from recombinant E. Coli cells","volume":"239","author":"Ward","year":"1992","journal-title":"J Mol Biol"},{"key":"2023072506545038700_B27","first-page":"508","article-title":"In vivoelimination of T cells expressing specific T-cell receptor V\u03b2 chains in mice susceptible to collagen-induced arthritis","volume":"69","author":"Goldschmidt","year":"1990","journal-title":"Immunology"},{"key":"2023072506545038700_B28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1084\/jem.169.1.27","article-title":"Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V\u03b1 and V\u03b2 chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different","volume":"169","author":"Burns","year":"1989","journal-title":"J Exp Med"},{"key":"2023072506545038700_B29","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF00189971","article-title":"Neuritogenic Lewis rat T cells use TCR \u03b2 chains that include a new TCR V\u03b28 family member","volume":"40","author":"Zhang","year":"1994","journal-title":"Immunogenetics"},{"key":"2023072506545038700_B30","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.4049\/jimmunol.151.3.1627","article-title":"Evidence for selective accumulation of V\u03b28 T lymphocytes in experimental autoimmune uveoretinitis induced with two different retinal antigens","volume":"151","author":"Egwuagu","year":"1993","journal-title":"J Immunol"},{"key":"2023072506545038700_B31","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.4049\/jimmunol.156.4.1654","article-title":"Establishment and characterization of a murine CD4 T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice","volume":"156","author":"Rizzo","year":"1996","journal-title":"J Immunol"},{"key":"2023072506545038700_B32","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4049\/jimmunol.154.1.388","article-title":"Experimental autoimmune encephalomyelitis\u2013resistant mice have highly encephalitogenic MBP-specific T cell clones that recognize a MBP peptide with high affinity for MHC class II","volume":"154","author":"Abromson-Leeman","year":"1995","journal-title":"J Immunol"},{"key":"2023072506545038700_B33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/cimm.1996.0133","article-title":"Mechanism of the development of autoimmune dacryoadenitis in the mouse model for primary Sjogren's syndrome","volume":"170","author":"Takahashi","year":"1996","journal-title":"Cell Immunol"},{"key":"2023072506545038700_B34","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/art.1780380809","article-title":"Biased T cell receptor V\u03b2 gene usage during specific stages of the development of autoimmune sialadenitis in the mrl\/lprmouse model of Sjogren's syndrome","volume":"38","author":"Hayashi","year":"1995","journal-title":"Arthritis Rheum"},{"key":"2023072506545038700_B35","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.2337\/diab.38.11.1492","article-title":"Prevention of cyclophosphamide-induced diabetes by anti-V\u03b28 T cell receptor monoclonal antibody therapy in NOD\/Wehi mice","volume":"38","author":"Bacelj","year":"1989","journal-title":"Diabetes"},{"key":"2023072506545038700_B36","doi-asserted-by":"crossref","first-page":"879","DOI":"10.4049\/jimmunol.146.3.879","article-title":"Identification of V\u03b24bearing T cells in SJL\/J mice. Further evidence for the V region disease hypothesis?","volume":"146","author":"Padula","year":"1991","journal-title":"J Immunol"},{"key":"2023072506545038700_B37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/(SICI)1097-4547(19960115)43:2<137::AID-JNR2>3.0.CO;2-H","article-title":"Natural immunodominant and EAEprotective determinant within the Lewis rat V\u03b28.2 sequence include CDR2 and framework 3 idiotopes","volume":"43","author":"Vainiene","year":"1996","journal-title":"J Neurosci Res"},{"key":"2023072506545038700_B38","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1172\/JCI118741","article-title":"Immunization with T cell receptor V\u03b2 chain peptides deletes pathogenic T cells and prevents the induction of collagen- induced arthritis in mice","volume":"97","author":"Haqqi","year":"1996","journal-title":"J Clin Invest"},{"key":"2023072506545038700_B39","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.4049\/jimmunol.155.9.4504","article-title":"Vaccination with a recombinant V alpha domain of a TCR prevents the development of collagen-induced arthritis","volume":"155","author":"Rosloniec","year":"1995","journal-title":"J Immunol"},{"key":"2023072506545038700_B40","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1126\/science.2471264","article-title":"Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells","volume":"244","author":"Lohse","year":"1989","journal-title":"Science (Wash DC)"}],"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/185\/10\/1725\/1679240\/5534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/185\/10\/1725\/1679240\/5534.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:23:32Z","timestamp":1690269812000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/185\/10\/1725\/25097\/Regulatory-T-Cells-Specific-for-the-Same-Framework"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5,19]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,5,19]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.185.10.1725","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5,19]]}}}