{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:24:44Z","timestamp":1791599084373,"version":"4.3.4"},"reference-count":47,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,3,3]]},"abstract":"<jats:p>After antigen capture, dendritic cells (DC) migrate into T cell\u2013rich areas of secondary lymphoid organs, where they induce T cell activation, that subsequently drives B cell activation. Here, we investigate whether DC, generated in vitro, can directly modulate B cell responses, using CD40L-transfected L cells as surrogate activated T cells. DC, through the production of soluble mediators, stimulated by 3- to 6-fold the proliferation and subsequent recovery of B cells. Furthermore, after CD40 ligation, DC enhanced by 30\u2013300-fold the secretion of IgG and IgA by sIgD\u2212 B cells (essentially memory B cells). In the presence of DC, naive sIgD+ B cells produced, in response to interleukin-2, large amounts of IgM. Thus, in addition to activating naive T cells in the extrafollicular areas of secondary lymphoid organs, DC may directly modulate B cell growth and differentiation.<\/jats:p>","DOI":"10.1084\/jem.185.5.941","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"941-952","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":210,"title":["Dendritic Cells Enhance Growth and Differentiation of CD40-activated B Lymphocytes"],"prefix":"10.1084","volume":"185","author":[{"given":"Bertrand","family":"Dubois","sequence":"first","affiliation":[{"name":"From *Schering Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and the \u2021Department of Nephrology, Leiden University Hospital, 2333 Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Vanbervliet","sequence":"additional","affiliation":[{"name":"From *Schering Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and the \u2021Department of Nephrology, Leiden University Hospital, 2333 Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome","family":"Fayette","sequence":"additional","affiliation":[{"name":"From *Schering Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and the \u2021Department of Nephrology, Leiden University Hospital, 2333 Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Massacrier","sequence":"additional","affiliation":[{"name":"From *Schering Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and the \u2021Department of Nephrology, Leiden University Hospital, 2333 Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees Van","family":"Kooten","sequence":"additional","affiliation":[{"name":"From *Schering Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and the \u2021Department of Nephrology, Leiden University Hospital, 2333 Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Bri\u00e8re","sequence":"additional","affiliation":[{"name":"From *Schering Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and the \u2021Department of Nephrology, Leiden University Hospital, 2333 Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Banchereau","sequence":"additional","affiliation":[{"name":"From *Schering Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and the \u2021Department of Nephrology, Leiden University Hospital, 2333 Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Caux","sequence":"additional","affiliation":[{"name":"From *Schering Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and the \u2021Department of Nephrology, Leiden University Hospital, 2333 Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1997,3,3]]},"reference":[{"key":"2023072507162583100_B1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.iy.09.040191.001415","article-title":"The dendritic cell system and its role in immunogenicity","volume":"9","author":"Steinman","year":"1991","journal-title":"Annu Rev Immunol"},{"key":"2023072507162583100_B2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/367425a0","article-title":"How B and T cells talk to each other","volume":"367","author":"Clark","year":"1994","journal-title":"Nature 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