{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:29:21Z","timestamp":1792099761262,"version":"4.4.0"},"reference-count":45,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,3,17]]},"abstract":"<jats:p>A subset of CD4+CD11c\u2212CD3\u2212 blood cells was recently shown to develop into dendritic cells when cultured with monocyte conditioned medium. Here, we demonstrate that CD4+ CD11c\u2212CD3\u2212 cells, isolated from tonsils, correspond to the so-called plasmacytoid T cells, an obscure cell type that has long been observed by pathologists within secondary lymphoid tissues. They express CD45RA, but not markers specific for known lymphoid- or myeloid-derived cell types. They undergo rapid apoptosis in culture, unless rescued by IL-3. Further addition of CD40-ligand results in their differentiation into dendritic cells that express low levels of myeloid antigens CD13 and CD33.<\/jats:p>","DOI":"10.1084\/jem.185.6.1101","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:49:30Z","timestamp":1027687770000},"page":"1101-1112","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":929,"title":["The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand"],"prefix":"10.1084","volume":"185","author":[{"given":"G\u00e9raldine","family":"Grouard","sequence":"first","affiliation":[{"name":"From *Schering-Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and \u2021Institute of Anatomy, Division of Cell Biology, University Irchel-Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Clotilde","family":"Rissoan","sequence":"additional","affiliation":[{"name":"From *Schering-Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and \u2021Institute of Anatomy, Division of Cell Biology, University Irchel-Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Filgueira","sequence":"additional","affiliation":[{"name":"From *Schering-Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and \u2021Institute of Anatomy, Division of Cell Biology, University Irchel-Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Durand","sequence":"additional","affiliation":[{"name":"From *Schering-Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and \u2021Institute of Anatomy, Division of Cell Biology, University Irchel-Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Banchereau","sequence":"additional","affiliation":[{"name":"From *Schering-Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and \u2021Institute of Anatomy, Division of Cell Biology, University Irchel-Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"From *Schering-Plough, Laboratory for Immunological Research, 69571 Dardilly, France; and \u2021Institute of Anatomy, Division of Cell Biology, University Irchel-Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1997,3,17]]},"reference":[{"key":"2023072915213992900_B1","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0140-6736(75)91974-1","article-title":"T-associated plasma cells","volume":"1","author":"Lennert","year":"1975","journal-title":"Lancet"},{"key":"2023072915213992900_B2"},{"key":"2023072915213992900_B3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF02932940","article-title":"Comparative immunostaining of T-associated plasma cells and other lymph-node cells in paraffin section","volume":"43","author":"Papadimitriou","year":"1983","journal-title":"Virchows Arch (Cell Pathol)"},{"key":"2023072915213992900_B4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0046-8177(87)80189-2","article-title":"Immunocytology of plasmacytoid T cells: marker analysis indicates a unique phenotype of this enigmatic cell","volume":"18","author":"Horny","year":"1986","journal-title":"Hum Pathol"},{"key":"2023072915213992900_B5","first-page":"225","article-title":"The plasmacytoid monocyte (the so called plasmacytoid T-cell). 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