{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:21:01Z","timestamp":1790266861943,"version":"4.1.0"},"reference-count":26,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,4,21]]},"abstract":"<jats:p>The homing of lymphocytes from the blood is controlled by specialized processes of lymphocyte\u2013endothelial cell interaction. Interference with these processes offers the potential to manipulate lymphocyte traffic, and thus to modulate normal and pathologic immune and inflammatory responses. We selected antilymphocyte monoclonal antibodies (mAbs) for inhibition of lymphocyte binding in vitro to lymph node high endothelial venules (HEV), specialized vessels that support lymphocyte recruitment into lymph nodes. mAb L11 blocks T cell binding to lymph node and Peyer's patch HEV and inhibits T cell extravasation from the blood into organized secondary lymphoid tissues. In contrast, L11 has no effect on lymphocyte binding to purified vascular ligands for L-selectin, \u03b14\u03b27, or LFA-1, suggesting that it inhibits by a novel mechanism. The L11 antigen is CD43, a sialomucin implicated in vitro in regulation of lymphocyte activation, whose expression is often dysregulated in the Wiskott-Aldrich syndrome. CD43 represents a novel target for experimental and therapeutic manipulation of lymphocyte traffic and may help regulate T cell distribution in vivo.<\/jats:p>","DOI":"10.1084\/jem.185.8.1493","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1493-1498","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Anti-CD43 Inhibition of \u2009T Cell Homing"],"prefix":"10.1084","volume":"185","author":[{"given":"Leslie M.","family":"McEvoy","sequence":"first","affiliation":[{"name":"From the *Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, Stanford, California 94305; \u2021Center for Molecular Biology and Medicine, Veterans Affairs Health Care System, Palo Alto, California 94304; and \u00a7Department of Microbiology and Immunology, The Cancer Center of the University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"},{"name":"From the *Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, Stanford, California 94305; \u2021Center for Molecular Biology and Medicine, Veterans Affairs Health Care System, Palo Alto, California 94304; and \u00a7Department of Microbiology and Immunology, The Cancer Center of the University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailing","family":"Sun","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, Stanford, California 94305; \u2021Center for Molecular Biology and Medicine, Veterans Affairs Health Care System, Palo Alto, California 94304; and \u00a7Department of Microbiology and Immunology, The Cancer Center of the University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"},{"name":"From the *Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, Stanford, California 94305; \u2021Center for Molecular Biology and Medicine, Veterans Affairs Health Care System, Palo Alto, California 94304; and \u00a7Department of Microbiology and Immunology, The Cancer Center of the University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Frelinger","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, Stanford, California 94305; \u2021Center for Molecular Biology and Medicine, Veterans Affairs Health Care System, Palo Alto, California 94304; and \u00a7Department of Microbiology and Immunology, The Cancer Center of the University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene C.","family":"Butcher","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, Stanford, California 94305; \u2021Center for Molecular Biology and Medicine, Veterans Affairs Health Care System, Palo Alto, California 94304; and \u00a7Department of Microbiology and Immunology, The Cancer Center of the University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"},{"name":"From the *Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, Stanford, California 94305; \u2021Center for Molecular Biology and Medicine, Veterans Affairs Health Care System, Palo Alto, California 94304; and \u00a7Department of Microbiology and Immunology, The Cancer Center of the University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1997,4,21]]},"reference":[{"key":"2023072507122030300_B1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0092-8674(91)90279-8","article-title":"Leukocyte\u2013endothelial cell recognition: three (or more) steps to specificity and diversity","volume":"67","author":"Butcher","year":"1991","journal-title":"Cell"},{"key":"2023072507122030300_B2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.272.5258.60","article-title":"Lymphocyte homing and homeostasis","volume":"272","author":"Butcher","year":"1996","journal-title":"Science (Wash DC)"},{"key":"2023072507122030300_B3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0167-5699(92)90151-V","article-title":"Lymphocyte interactions with endothelial cells","volume":"13","author":"Shimizu","year":"1992","journal-title":"Immunol Today"},{"key":"2023072507122030300_B4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","article-title":"Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm","volume":"76","author":"Springer","year":"1994","journal-title":"Cell"},{"key":"2023072507122030300_B5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/1074-7613(95)90162-0","article-title":"Distinct roles of L-selectin and integrins alpha 4 beta 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: the multistep model confirmed and refined","volume":"3","author":"Bargatze","year":"1995","journal-title":"Immunity"},{"key":"2023072507122030300_B6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/304030a0","article-title":"A cell-surface molecule involved in organ-specific homing of lymphocytes","volume":"303","author":"Gallatin","year":"1983","journal-title":"Nature (Lond)"},{"key":"2023072507122030300_B7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0008-8749(90)90235-J","article-title":"Mechanisms of pertussis toxin inhibition of lymphocyte\u2013HEV interactions. 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