{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:14:51Z","timestamp":1789236891968,"version":"build-2803163510"},"reference-count":82,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,5,5]]},"abstract":"<jats:p>The murine \u03b3-herpesvirus 68 has many similarities to EBV, and induces a syndrome comparable to infectious mononucleosis (IM). The frequency of activated CD8+ T cells (CD62Llo) in the peripheral blood increased greater than fourfold by 21 d after infection of C57BL\/6J (H-2b) mice, and remained high for at least a further month. The spectrum of T cell receptor usage was greatly skewed, with as many as 75% of the CD8+ T cells in the blood expressing a V\u03b24+ phenotype. Interestingly, the V\u03b24 dominance was also seen, to varying extents, in H-2k, H-2d, H-2u, and H-2q strains of mice. In addition, although CD4 depletion from day 11 had no effect on the V\u03b24 bias of the T cells, the V\u03b24+CD8+ expansion was absent in H-2IAb\u2013deficient congenic mice. However, the numbers of cycling cells in the CD4 antibody\u2013depleted mice and mice that are CD4 deficient as a consequence of the deletion of MHC class II, were generally lower. The findings suggest that the IM-like disease is driven both by cytokines provided by CD4+ T cells and by a viral superantigen presented by MHC class II glycoproteins to V\u03b24+CD8+ T cells.<\/jats:p>","DOI":"10.1084\/jem.185.9.1641","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1641-1650","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":128,"title":["Pathogenesis of an Infectious Mononucleosis-like Disease Induced by a Murine \u03b3-Herpesvirus: Role for a Viral Superantigen?"],"prefix":"10.1084","volume":"185","author":[{"given":"Ralph A.","family":"Tripp","sequence":"first","affiliation":[{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Marie","family":"Hamilton-Easton","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda D.","family":"Cardin","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick G.","family":"Behm","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Woodland","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"},{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Doherty","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"},{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"},{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia A.","family":"Blackman","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 38163"},{"name":"From the *Department of Immunology, \u2021Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; and the \u00a7Department of Pediatrics, \u2016Department of Pathology, University of Tennessee, Memphis, Tennessee 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