{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:36:47Z","timestamp":1790890607394,"version":"4.1.0"},"reference-count":26,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,5,5]]},"abstract":"<jats:p>In Leishmaniasis, as in many infectious diseases, clinical manifestations are determined by the interaction between the genetics of the host and of the parasite. Here we describe studies mapping two loci controlling resistance to murine cutaneous leishmaniasis. Mice infected with L. major show marked genetic differences in disease manifestations: BALB\/c mice are susceptible, exhibiting enlarging lesions that progress to systemic disease and death, whereas C57BL\/6 are resistant, developing small, self-healing lesions. F2 animals from a C57BL\/6 \u00d7 BALB\/c cross showed a continuous distribution of lesion score. Quantitative trait loci (QTL) have been mapped after a non-parametric QTL analysis on a genome-wide scan on 199 animals. QTLs identified were confirmed in a second cross of 271 animals. Linkage was confirmed to a chromosome 9 locus (D9Mit67\u2013D9Mit71) and to a region including the H2 locus on chromosome 17. These have been named lmr2 and lmr1, respectively.<\/jats:p>","DOI":"10.1084\/jem.185.9.1705","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1705-1710","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":68,"title":["Resistance to <i>Leishmania major<\/i> is Linked to the H2 Region on Chromosome 17 and to Chromosome 9"],"prefix":"10.1084","volume":"185","author":[{"given":"Lynden J.","family":"Roberts","sequence":"first","affiliation":[{"name":"From the The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey M.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"From the The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Curtis","sequence":"additional","affiliation":[{"name":"From the The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Handman","sequence":"additional","affiliation":[{"name":"From the The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Foote","sequence":"additional","affiliation":[{"name":"From the The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1997,5,5]]},"reference":[{"key":"2023072915182697000_B1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0035-9203(72)90306-9","article-title":"Diffuse cutaneous leishmaniasis: a disease due to an immunological defect of the host","volume":"66","author":"Convit","year":"1972","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2023072915182697000_B2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/250353a0","article-title":"Genetic control of natural resistance to Leishmania donovani.","volume":"250","author":"Bradley","year":"1974","journal-title":"Nature (Lond)"},{"key":"2023072915182697000_B3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-3024.1980.tb00061.x","article-title":"Immunological regulation of experimental cutaneous leishmaniasis. 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