{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:50:18Z","timestamp":1791903018199,"version":"4.3.4"},"reference-count":29,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,7,7]]},"abstract":"<jats:p>The human CC chemokine I-309 is a potent monocyte chemoattractant and inhibits apoptosis in thymic cell lines. Here, we identify a specific human I-309 receptor, and name it CCR8 according to an accepted nomenclature system. The receptor has seven predicted transmembrane domains, is expressed constitutively in monocytes and thymus, and is encoded by a previously reported gene of previously unknown function named, alternatively, CY6, TER1, and CKR-L1. After transfection with the CY6 open reading frame, a mouse pre\u2013B cell line exhibited calcium flux and chemotaxis in response to I-309 (EC50 = 2 nM for each), whereas 20 other chemokines were inactive. Signaling was sensitive to pertussis toxin, suggesting coupling to a Gi-type G protein. These properties parallel those of endogenous I-309 receptors expressed in an HL-60 clone 15 cell line model. The apparent monogamous relationship between I-309 and CCR8 is unusual among known CC chemokines and known CC chemokine receptors. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis.<\/jats:p>","DOI":"10.1084\/jem.186.1.165","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:49:30Z","timestamp":1027687770000},"page":"165-170","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":174,"title":["Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309"],"prefix":"10.1084","volume":"186","author":[{"given":"H. Lee","family":"Tiffany","sequence":"first","affiliation":[{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L.","family":"Lautens","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Liang","family":"Gao","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Pease","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"},{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Locati","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Combadiere","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Modi","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom I.","family":"Bonner","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"},{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Murphy","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the \u2021Laboratory of Cell Biology and \u00a7Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892; \u2016the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the \u00b6Biological Carcinogenesis and Development Program, Program Resources, Incorporated\/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1997,7,7]]},"reference":[{"key":"2023072915283764900_B1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0065-2776(08)60509-X","article-title":"Interleukin-8 and related chemotactic cytokines\u2014CXC and CC chemokines","volume":"55","author":"Baggiolini","year":"1994","journal-title":"Adv Immunol"},{"key":"2023072915283764900_B2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/385640a0","article-title":"A new class of membrane-bound chemokine with a CX3C motif","volume":"385","author":"Bazan","year":"1997","journal-title":"Nature (Lond)"},{"key":"2023072915283764900_B3","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1126\/science.7973732","article-title":"Lymphotactin: a cytokine that represents a new class of chemokine","volume":"266","author":"Kelner","year":"1994","journal-title":"Science (Wash DC)"},{"key":"2023072915283764900_B4","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.4049\/jimmunol.145.8.2737","article-title":"Sequence and chromosomal location of the I-309 gene. 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