{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:07:59Z","timestamp":1792058879920,"version":"4.4.0"},"reference-count":60,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,8,4]]},"abstract":"<jats:p>The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells. To investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6\u2212\/\u2212RM). Lymphogenesis in primary lymphoid tissues of Bcl6\u2212\/\u2212RM is normal, and Bcl6\u2212\/\u2212RM produced control levels of primary IgG1 antibodies specific to T cell\u2013dependent antigens. However, GCs were not found in these mice. This defect was mainly due to the abnormalities of B cells. Therefore, Bcl6 is essential for the differentiation of GC B cells.<\/jats:p>","DOI":"10.1084\/jem.186.3.439","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:49:30Z","timestamp":1027687770000},"page":"439-448","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":323,"title":["Disruption of the\n                    <i>Bcl6<\/i>\n                    Gene Results in an Impaired Germinal Center Formation"],"prefix":"10.1084","volume":"186","author":[{"given":"Tetsuya","family":"Fukuda","sequence":"first","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"},{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Okada","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Hatano","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Miki","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Okabe","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Koseki","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsaku","family":"Hirosawa","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Miyasaka","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tokuhisa","sequence":"additional","affiliation":[{"name":"From the *Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan; the \u2021First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan; and the \u00a7Core Research for Evolutional Science and Technology, Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1997,8,4]]},"reference":[{"key":"2023072507261924500_B1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ng0993-66","article-title":"LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas","volume":"5","author":"Kerchaert","year":"1993","journal-title":"Nature Genet"},{"key":"2023072507261924500_B2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.8235596","article-title":"Alterations of a zinc finger\u2013encoding gene, BCL-6, in diffuse large-cell lymphoma","volume":"262","author":"Ye","year":"1993","journal-title":"Science (Wash DC)"},{"key":"2023072507261924500_B3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1182\/blood.V83.1.26.26","article-title":"Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kr\u00fcppel-like zinc-finger protein","volume":"83","author":"Miki","year":"1994","journal-title":"Blood"},{"key":"2023072507261924500_B4","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1182\/blood.V83.9.2423.2423","article-title":"LAZ3rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome","volume":"83","author":"Bastard","year":"1994","journal-title":"Blood"},{"key":"2023072507261924500_B5","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1182\/blood.V83.7.1757.1757","article-title":"Rearrangements of the BCL6gene in diffuse large cell non-Hodgkin's lymphoma","volume":"83","author":"Lo Coco, F., B.H. Ye, F. Lista., P. Corradini, K. Offit, R. Knoeles, R.S.K. Chaganti, and R. Dalla-Favera","year":"1994","journal-title":"Blood"},{"key":"2023072507261924500_B6","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1002\/j.1460-2075.1995.tb00311.x","article-title":"Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma","volume":"14","author":"Ye","year":"1995","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"2023072507261924500_B7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood.V86.1.45.bloodjournal86145","article-title":"BCL-6 protein is expressed in germinal-center B cells","volume":"86","author":"Cattoretti","year":"1995","journal-title":"Blood"},{"key":"2023072507261924500_B8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1182\/blood.V86.1.28.bloodjournal86128","article-title":"BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts","volume":"86","author":"Onizuka","year":"1995","journal-title":"Blood"},{"key":"2023072507261924500_B9","first-page":"1657","article-title":"The murine BCL6gene is induced in activated lymphocytes as an immediate early gene","volume":"11","author":"Fukuda","year":"1995","journal-title":"Oncogene"},{"key":"2023072507261924500_B10","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/bbrc.1994.2468","article-title":"Recognition DNA sequence of a novel putative transcription factor, BCL6","volume":"204","author":"Kawamata","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"2023072507261924500_B11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/gcc.2870130314","article-title":"BCL6 encodes a sequence-specific DNA-binding protein","volume":"13","author":"Baron","year":"1995","journal-title":"Genes Chromosomes 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Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance","volume":"182","author":"Han","year":"1995","journal-title":"J Exp Med"},{"key":"2023072507261924500_B29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/375331a0","article-title":"Soluble antigen can cause enhanced apoptosis of germinal-centre B cells","volume":"375","author":"Pulendran","year":"1995","journal-title":"Nature (Lond)"},{"key":"2023072507261924500_B30","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/375334a0","article-title":"Antigen-induced B-cell death and elimination during germinal-centre immune responses","volume":"375","author":"Shokat","year":"1995","journal-title":"Nature (Lond)"},{"key":"2023072507261924500_B31","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1002\/eji.1830211209","article-title":"Sites of specific B cell activation in primary and secondary responses to T cell\u2013dependent and T cell\u2013independent antigens","volume":"21","author":"Liu","year":"1991","journal-title":"Eur J Immunol"},{"key":"2023072507261924500_B32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1126\/science.7537388","article-title":"Generation of memory B cells and plasma cells in vitro","volume":"268","author":"Arpin","year":"1995","journal-title":"Science (Wash DC)"},{"key":"2023072507261924500_B33","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","article-title":"RAG-1\u2013deficient mice have no mature B and T lymphocytes","volume":"68","author":"Mombaerts","year":"1992","journal-title":"Cell"},{"key":"2023072507261924500_B34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/intimm\/3.4.369","article-title":"IgG response is impaired in H2\u2013c-fos transgenic mice","volume":"3","author":"Takao","year":"1991","journal-title":"Int Immunol"},{"key":"2023072507261924500_B35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/eji.1830180115","article-title":"Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors","volume":"18","author":"Karasuyama","year":"1988","journal-title":"Eur J Immunol"},{"key":"2023072507261924500_B36","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1084\/jem.173.5.1165","article-title":"In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. 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