{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:32:40Z","timestamp":1790015560841,"version":"4.0.1"},"reference-count":30,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,8,4]]},"abstract":"<jats:p>Mast cells are the main effector cells of immediate hypersensitivity and anaphylaxis. Their role in the development of allergen-induced airway hyperresponsiveness (AHR) is controversial and based on indirect evidence. To address these issues, mast cell\u2013deficient mice (W\/W\u2009\u2009v) and their congenic littermates were sensitized to ovalbumin (OVA) by intraperitoneal injection and subsequently challenged with OVA via the airways. Comparison of OVA-specific immunoglobulin E (IgE) levels in the serum and numbers of eosinophils in bronchoalveolar lavage fluid or lung digests showed no differences between the two groups of mice. Further, measurements of airway resistance and dynamic compliance at baseline and after inhalation of methacholine were similar. These data indicate that mast cells or IgE\u2013mast cell activation is not required for the development of eosinophilic inflammation and AHR in mice sensitized to allergen via the intraperitoneal route and challenged via the airways.<\/jats:p>","DOI":"10.1084\/jem.186.3.449","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"449-454","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":300,"title":["Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness in Mast Cell\u2013deficient Mice"],"prefix":"10.1084","volume":"186","author":[{"given":"K.","family":"Takeda","sequence":"first","affiliation":[{"name":"From the *Division of Basic Sciences and Pulmonary Medicine, Department of Pediatrics, and the \u2021Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado; and \u00a7The Jackson Laboratory, Bar Harbor, Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hamelmann","sequence":"additional","affiliation":[{"name":"From the *Division of Basic Sciences and Pulmonary Medicine, Department of Pediatrics, and the \u2021Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado; and \u00a7The Jackson Laboratory, Bar Harbor, Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Joetham","sequence":"additional","affiliation":[{"name":"From the *Division of Basic Sciences and Pulmonary Medicine, Department of Pediatrics, and the \u2021Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado; and \u00a7The Jackson Laboratory, Bar Harbor, Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.D.","family":"Shultz","sequence":"additional","affiliation":[{"name":"From the *Division of Basic Sciences and Pulmonary Medicine, Department of Pediatrics, and the \u2021Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado; and \u00a7The Jackson Laboratory, Bar Harbor, Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.L.","family":"Larsen","sequence":"additional","affiliation":[{"name":"From the *Division of Basic Sciences and Pulmonary Medicine, Department of Pediatrics, and the \u2021Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado; 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