{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:22:27Z","timestamp":1790515347026,"version":"4.1.0"},"reference-count":33,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,8,29]]},"abstract":"<jats:p>We recently demonstrated that gene-targeted disruption of the C5a anaphylatoxin receptor prevented lung injury in immune complex\u2013mediated inflammation. In this study, we compare the effect of C5aR deficiency in immune complex\u2013induced inflammation in the peritoneal cavity and skin with the results derived from our immune complex alveolitis model. C5aR- deficient mice exhibit decreased migration of neutrophils and decreased levels of TNF-\u03b1 and interleukin 6 in the peritoneal reverse passive Arthus reaction compared to their wild-type littermates. In the reverse passive Arthus reaction in the skin the C5aR was also required for the full expression of neutrophil influx and edema formation; C5aR-deficient mice showed reduced neutrophil migration and microvascular permeability changes. In contrast to our studies in immune complex\u2013induced lung inflammation, C5aR deficiency does not completely prevent injury in the peritoneal cavity and skin. These data indicate a dominant role for the C5aR and its ligand in the reverse passive Arthus reaction in the lung and a synergistic role together with other inflammatory mediators in immune complex\u2013mediated peritonitis and skin injury.<\/jats:p>","DOI":"10.1084\/jem.186.5.749","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":135,"title":["Impaired Inflammatory Responses in the Reverse Arthus Reaction Through Genetic Deletion of the C5a Receptor"],"prefix":"10.1084","volume":"186","author":[{"given":"Uta E.","family":"H\u00f6pken","sequence":"first","affiliation":[{"name":"From the *Ina Sue Perlmutter Cystic Fibrosis Laboratory and Department of Pediatrics, Children's Hospital, Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Lu","sequence":"additional","affiliation":[{"name":"From the *Ina Sue Perlmutter Cystic Fibrosis Laboratory and Department of Pediatrics, Children's Hospital, Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma P.","family":"Gerard","sequence":"additional","affiliation":[{"name":"From the *Ina Sue Perlmutter Cystic Fibrosis Laboratory and Department of Pediatrics, Children's Hospital, Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Gerard","sequence":"additional","affiliation":[{"name":"From the *Ina Sue Perlmutter Cystic Fibrosis Laboratory and Department of Pediatrics, Children's Hospital, Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1997,8,29]]},"reference":[{"key":"2023072507345632800_B1","first-page":"817","article-title":"Injections r\u00e9p\u00e9t\u00e9es de s\u00e9rum de cheval chez le lapin","volume":"55","author":"Arthus","year":"1903","journal-title":"Soc Biol"},{"key":"2023072507345632800_B2"},{"key":"2023072507345632800_B3","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1146\/annurev.iy.12.040194.004015","article-title":"C5a anaphylatoxin and its seven transmembrane-segment receptor","volume":"12","author":"Gerard","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"2023072507345632800_B4"},{"key":"2023072507345632800_B5","first-page":"1067","article-title":"Release of histamine from rat mast cells by complement peptides C3a and C5a","volume":"28","author":"Johnson","year":"1975","journal-title":"Immunology"},{"key":"2023072507345632800_B6","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.4049\/jimmunol.139.8.2635","article-title":"C5a induction of human interleukin 1. 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