{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:50:32Z","timestamp":1790869832205,"version":"4.1.0"},"reference-count":41,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,8,29]]},"abstract":"<jats:p>Recent understanding of the mechanism of immunoglobulin G (IgG) catabolism has yielded new insight into antibody-mediated diseases. We proposed that \u03b22-microglobulin (\u03b22m)\u2013deficient mice have been protected from systemic lupus erythematosis (SLE)\u2013like syndromes because they lack the \u03b22m-associated IgG protection receptor (FcRn) and therefore catabolize IgG, including pathogenic IgG autoantibodies, considerably more rapidly than normal mice. Such an hypothesis would predict that \u03b22m-deficient mice would also be resistant to experimental bullous pemphigoid, a disease with a pathogenesis thought to be much simpler than SLE, being the result of antibody directed toward a pathogenic epitope on the epidermal hemidesmosome that anchors basal keratinocytes to the basement membrane. To test this hypothesis, we administered pathogenic rabbit antibody directed toward the hemidesmosome to \u03b22m-deficient mice and to normal control mice, both intraperitoneally and intradermally, and assessed the mice clinically, histologically, and immunologically for manifestations of skin disease. We found that the \u03b22m-deficient mice were protected when the antibody was given intraperitoneally whereas intradermal administration resulted in blisters only slightly less severe than those seen in normal mice. These data would indicate that autoantibody-mediated inflammation might be prevented or controlled by appropriate modulation of FcRn function.<\/jats:p>","DOI":"10.1084\/jem.186.5.777","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"777-783","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["\u03b22-microglobulin\u2013deficient Mice Are Resistant to Bullous Pemphigoid"],"prefix":"10.1084","volume":"186","author":[{"given":"Zhi","family":"Liu","sequence":"first","affiliation":[{"name":"From the *Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 43226; \u2021The Jackson Laboratory, Bar Harbor, Maine 04609; and the \u00a7Department of Internal Medicine and the \u2016Department of Pathology, The Ohio State University, Columbus, Ohio 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derry C.","family":"Roopenian","sequence":"additional","affiliation":[{"name":"From the *Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 43226; \u2021The Jackson Laboratory, Bar Harbor, Maine 04609; and the \u00a7Department of Internal Medicine and the \u2016Department of Pathology, The Ohio State University, Columbus, Ohio 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Zhou","sequence":"additional","affiliation":[{"name":"From the *Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 43226; \u2021The Jackson Laboratory, Bar Harbor, Maine 04609; and the \u00a7Department of Internal Medicine and the \u2016Department of Pathology, The Ohio State University, Columbus, Ohio 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg 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