{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:34:06Z","timestamp":1791239646264,"version":"4.1.0"},"reference-count":59,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,6,1]]},"abstract":"<jats:p>To investigate the possible involvement of DNA repair in the process of somatic hypermutation of rearranged immunoglobulin variable (V) region genes, we have analyzed the occurrence, frequency, distribution, and pattern of mutations in rearranged V\u03bb1 light chain genes from naive and memory B cells in DNA repair\u2013deficient mutant mouse strains. Hypermutation was found unaffected in mice carrying mutations in either of the following DNA repair genes: xeroderma pigmentosum complementation group (XP)A and XPD, Cockayne syndrome complementation group B (CSB), mutS homologue 2 (MSH2), radiation sensitivity 54 (RAD54), poly (ADP-ribose) polymerase (PARP), and 3-alkyladenine DNA-glycosylase (AAG). These results indicate that both subpathways of nucleotide excision repair, global genome repair, and transcription-coupled repair are not required for somatic hypermutation. This appears also to be true for mismatch repair, RAD54-dependent double-strand\u2013break repair, and AAG-mediated base excision repair.<\/jats:p>","DOI":"10.1084\/jem.187.11.1735","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:54Z","timestamp":1027702134000},"page":"1735-1743","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":89,"title":["Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair\u2013deficient Mice"],"prefix":"10.1084","volume":"187","author":[{"given":"Heinz","family":"Jacobs","sequence":"first","affiliation":[{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of Cellular Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands; the \u2016Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115"},{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of Cellular Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands; the \u2016Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosho","family":"Fukita","sequence":"additional","affiliation":[{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of Cellular Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands; the \u2016Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijsbertus T.J.","family":"van der Horst","sequence":"additional","affiliation":[{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of Cellular Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands; the \u2016Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 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Wind","sequence":"additional","affiliation":[{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of Cellular Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands; the \u2016Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bevin P.","family":"Engelward","sequence":"additional","affiliation":[{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of Cellular Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands; the \u2016Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leona","family":"Samson","sequence":"additional","affiliation":[{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of 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Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane M\u00e9nissier","family":"de Murcia","sequence":"additional","affiliation":[{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of Cellular Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands; the \u2016Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"de Murcia","sequence":"additional","affiliation":[{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of Cellular Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands; the \u2016Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein t","family":"e Riele","sequence":"additional","affiliation":[{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of Cellular Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands; the \u2016Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Rajewsky","sequence":"additional","affiliation":[{"name":"From the *Basel Institute for Immunology, CH-4005 Basel, Switzerland; the \u2021Institute for Genetics, University of Cologne, 50931 Cologne, Germany; the \u00a7Department of Cellular Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands; the \u2016Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; the \u00b6Department of Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands; the **Ecole Superieure de Biotechnologie de Strasbourg, Universit\u00e9 Louis Pasteur, F-67400 Illkirch-Graffenstaden, France; and the \u2020\u2020Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 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