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Immune complex localization to follicular dendritic cells within splenic follicles was lacking in C1qA\u2212\/\u2212 mice. The precursor frequency of antigen-specific T cells was similar in C1qA\u2212\/\u2212 and wild-type mice. However, analysis of cytokine production by primed T cells in response to keyhole limpet hemocyanin revealed a significant reduction in interferon-\u03b3 production in C1qA\u2212\/\u2212 mice compared with control mice, whereas interleukin 4 secretion was equivalent. These data suggest that the classical pathway of complement may influence the cytokine profile of antigen-specific T lymphocytes and the subsequent immune response.<\/jats:p>","DOI":"10.1084\/jem.187.11.1789","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1789-1797","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":80,"title":["T Cell\u2013dependent Immune Response in C1q-deficient Mice: Defective Interferon \u03b3 Production by Antigen-specific T Cells"],"prefix":"10.1084","volume":"187","author":[{"given":"Antony J.","family":"Cutler","sequence":"first","affiliation":[{"name":"From the *Rheumatology Section and \u2021Immunology Department, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom; and the \u00a7Department of Human Genetics, Sloan Kettering Institute, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Botto","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Section and \u2021Immunology Department, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom; and the \u00a7Department of Human Genetics, Sloan Kettering Institute, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"van Essen","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Section and \u2021Immunology Department, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom; and the \u00a7Department of Human Genetics, Sloan Kettering Institute, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Rivi","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Section and \u2021Immunology Department, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom; and the \u00a7Department of Human Genetics, Sloan Kettering Institute, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Davies","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Section and \u2021Immunology Department, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom; and the \u00a7Department of Human Genetics, Sloan Kettering Institute, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gray","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Section and \u2021Immunology Department, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom; and the \u00a7Department of Human Genetics, Sloan Kettering Institute, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Walport","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Section and \u2021Immunology Department, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom; and the \u00a7Department of Human Genetics, Sloan Kettering Institute, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1998,6,1]]},"reference":[{"key":"2023072507445997900_B1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/newbio237157a0","article-title":"Role of complement in induction of allergic response","volume":"237","author":"Pepys","year":"1972","journal-title":"Nat New Biol"},{"key":"2023072507445997900_B2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1084\/jem.140.1.126","article-title":"Role of complement in induction of antibody production in vivo. 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