{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:02:40Z","timestamp":1791223360595,"version":"4.1.0"},"reference-count":48,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,2,16]]},"abstract":"<jats:p>The orphan receptor CRF2-4 is a member of the class II cytokine receptor family (CRF2), which includes the interferon receptors, the interleukin (IL) 10 receptor, and tissue factor. CRFB4, the gene encoding CRF2-4, is located within a gene cluster on human chromosome 21 that comprises three interferon receptor subunits. To elucidate the role of CRF2-4, we disrupted the CRFB4 gene in mice by means of homologous recombination. Mice lacking CRF2-4 show no overt abnormalities, grow normally, and are fertile. CRF2-4 deficient cells are normally responsive to type I and type II interferons, but lack responsiveness to IL-10. By \u223c12 wk of age, the majority of mutant mice raised in a conventional facility developed a chronic colitis and splenomegaly. Thus, CRFB4 mutant mice recapitulate the phenotype of IL-10\u2013deficient mice. These findings suggest that CRF2-4 is essential for IL-10\u2013mediated effects and is a subunit of the IL-10 receptor.<\/jats:p>","DOI":"10.1084\/jem.187.4.571","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"571-578","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":307,"title":["The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor"],"prefix":"10.1084","volume":"187","author":[{"given":"Susan D.","family":"Spencer","sequence":"first","affiliation":[{"name":"From the *Genentech Inc., South San Francisco, California 94080; the \u2021Swiss Institute for Experimental Cancer Research, 1066 Epalinges s\/Lausanne, Switzerland; and the \u00a7Department of Surgery, San Francisco Veterans Affairs Medical Center, San Francisco, California 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the *Genentech Inc., South San Francisco, California 94080; the \u2021Swiss Institute for Experimental Cancer Research, 1066 Epalinges s\/Lausanne, Switzerland; and the \u00a7Department of Surgery, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bauer","sequence":"additional","affiliation":[{"name":"From the *Genentech Inc., South San Francisco, California 94080; the \u2021Swiss Institute for Experimental Cancer Research, 1066 Epalinges s\/Lausanne, Switzerland; and the \u00a7Department of Surgery, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Ryan","sequence":"additional","affiliation":[{"name":"From the *Genentech Inc., South San Francisco, California 94080; the \u2021Swiss Institute for Experimental Cancer Research, 1066 Epalinges s\/Lausanne, 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