{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:54:12Z","timestamp":1791305652310,"version":"4.3.1"},"reference-count":50,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,2,16]]},"abstract":"<jats:p>Monocyte chemoattractant protein 1 (MCP-1) is a CC chemokine that attracts monocytes, memory T lymphocytes, and natural killer cells. Because other chemokines have similar target cell specificities and because CCR2, a cloned MCP-1 receptor, binds other ligands, it has been uncertain whether MCP-1 plays a unique role in recruiting mononuclear cells in vivo. To address this question, we disrupted SCYA2 (the gene encoding MCP-1) and tested MCP-1\u2013deficient mice in models of inflammation. Despite normal numbers of circulating leukocytes and resident macrophages, MCP-1\u2212\/\u2212 mice were specifically unable to recruit monocytes 72 h after intraperitoneal thioglycollate administration. Similarly, accumulation of F4\/80+ monocytes in delayed-type hypersensitivity lesions was impaired, although the swelling response was normal. Development of secondary pulmonary granulomata in response to Schistosoma mansoni eggs was blunted in MCP-1\u2212\/\u2212 mice, as was expression of IL-4, IL-5, and interferon \u03b3 in splenocytes. In contrast, MCP-1\u2212\/\u2212 mice were indistinguishable from wild-type mice in their ability to clear Mycobacterium tuberculosis. Our data indicate that MCP-1 is uniquely essential for monocyte recruitment in several inflammatory models in vivo and influences expression of cytokines related to T helper responses.<\/jats:p>","DOI":"10.1084\/jem.187.4.601","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:49:30Z","timestamp":1027687770000},"page":"601-608","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":804,"title":["Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1\u2013deficient Mice"],"prefix":"10.1084","volume":"187","author":[{"given":"Bao","family":"Lu","sequence":"first","affiliation":[{"name":"From the *Department of Adult Oncology, Dana-Farber Cancer Institute, and the \u2021Perlmutter Laboratory, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; the \u00a7Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48105; and the \u00b6Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Rutledge","sequence":"additional","affiliation":[{"name":"From the *Department of Adult Oncology, Dana-Farber Cancer Institute, and the \u2021Perlmutter Laboratory, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; the \u00a7Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48105; and the \u00b6Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Gu","sequence":"additional","affiliation":[{"name":"From the *Department of Adult Oncology, Dana-Farber Cancer Institute, and the \u2021Perlmutter Laboratory, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; the \u00a7Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48105; and the \u00b6Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"From the *Department of Adult Oncology, Dana-Farber Cancer Institute, and the \u2021Perlmutter Laboratory, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; the \u00a7Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48105; and the \u00b6Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas W.","family":"Lukacs","sequence":"additional","affiliation":[{"name":"From the *Department of Adult Oncology, Dana-Farber Cancer Institute, and the \u2021Perlmutter Laboratory, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; the \u00a7Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48105; and the \u00b6Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Kunkel","sequence":"additional","affiliation":[{"name":"From the *Department of Adult Oncology, Dana-Farber Cancer Institute, and the \u2021Perlmutter Laboratory, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; the \u00a7Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48105; 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