{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:54:41Z","timestamp":1790898881091,"version":"4.1.0"},"reference-count":53,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,2,16]]},"abstract":"<jats:p>The effector functions of CD4+ T lymphocytes are generally thought to be controlled by distinct populations of regulatory T cells and their soluble products. The role of B cells in the regulation of CD4-dependent host responses is less well understood. Hepatic egg granuloma formation and fibrosis in murine schistosomiasis are dependent on CD4+ lymphocytes, and previous studies have implicated CD8+ T cells or cross-regulatory cytokines produced by T helper (Th) lymphocytes as controlling elements of this pathologic process. In this report, we demonstrate that B cell\u2013deficient (\u03bcMT) mice exposed to Schistosoma mansoni develop augmented tissue pathology and, more importantly, fail to undergo the spontaneous downmodulation in disease normally observed during late stages of infection. Unexpectedly, B cell deficiency did not significantly alter T cell proliferative response or cause a shift in the Th1\/Th2 balance. Since schistosome-infected Fc receptor\u2013deficient (FcR \u03b3 chain knockout) mice display the same exacerbated egg pathology as that observed in infected \u03bcMT mice, the B cell\u2013 dependent regulatory mechanism revealed by these experiments appears to require receptor-mediated cell triggering. Together, the data demonstrate that humoral immune response\/FcR interactions can play a major role in negatively controlling inflammatory disease induced by CD4+ T cells.<\/jats:p>","DOI":"10.1084\/jem.187.4.619","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"619-629","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":132,"title":["CD4+ T Cell\u2013mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell\u2013dependent Mechanism Requiring Fc Receptor Signaling"],"prefix":"10.1084","volume":"187","author":[{"given":"Dragana","family":"Jankovic","sequence":"first","affiliation":[{"name":"From the *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; \u2021The Biomedical Research Institute, Rockville, Maryland 20852; and \u00a7The Rockefeller University, 1230 York Avenue, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen W.","family":"Cheever","sequence":"additional","affiliation":[{"name":"From the *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; \u2021The Biomedical Research Institute, Rockville, Maryland 20852; and \u00a7The Rockefeller University, 1230 York Avenue, New York, New York 10021"},{"name":"From the *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; \u2021The Biomedical Research Institute, Rockville, Maryland 20852; and \u00a7The Rockefeller University, 1230 York Avenue, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika C.","family":"Kullberg","sequence":"additional","affiliation":[{"name":"From the *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; \u2021The Biomedical Research Institute, Rockville, Maryland 20852; and \u00a7The Rockefeller University, 1230 York Avenue, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Wynn","sequence":"additional","affiliation":[{"name":"From the *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; \u2021The Biomedical Research Institute, Rockville, Maryland 20852; and \u00a7The Rockefeller University, 1230 York Avenue, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Yap","sequence":"additional","affiliation":[{"name":"From the *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; \u2021The Biomedical Research Institute, Rockville, Maryland 20852; and \u00a7The Rockefeller University, 1230 York Avenue, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Caspar","sequence":"additional","affiliation":[{"name":"From the *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; \u2021The Biomedical Research Institute, Rockville, Maryland 20852; and \u00a7The Rockefeller University, 1230 York Avenue, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"From the *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; \u2021The Biomedical Research Institute, Rockville, Maryland 20852; and \u00a7The Rockefeller University, 1230 York Avenue, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Clynes","sequence":"additional","affiliation":[{"name":"From the *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; 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