{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:33:07Z","timestamp":1775521987990,"version":"3.50.1"},"reference-count":31,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,2,16]]},"abstract":"<jats:p>The effect of preexistent virus-neutralizing antibodies on the active induction of antiviral T cell responses was studied in two model infections in mice. Against the noncytopathic lymphocytic choriomeningitis virus (LCMV), pretreatment with neutralizing antibodies conferred immediate protection against systemic virus spread and controlled the virus below detectable levels. However, presence of protective antibody serum titers did not impair induction of antiviral cytotoxic T lymphocyte (CTL) responses after infection with 102 PFU of LCMV. These CTLs efficiently protected mice independent of antibodies against challenge with LCMV\u2013glycoprotein recombinant vaccinia virus; they also protected against otherwise lethal lymphocytic choriomeningitis caused by intracerebral challenge with LCMV-WE, whereas transfused antibodies alone did not protect, and in some cases even enhanced, lethal lymphocytic choriomeningitis. Against the cytopathic vesicular stomatitis virus (VSV), specific CTLs and Th cells were induced in the presence of high titers of VSV-neutralizing antibodies after infection with 106 PFU of VSV, but not at lower virus doses. Taken together, preexistent protective antibody titers controlled infection but did not impair induction of protective T cell immunity. This is particularly relevant for noncytopathic virus infections since both virus-neutralizing antibodies and CTLs are essential for continuous virus control. Therefore, to vaccinate against such viruses parallel or sequential passive and active immunization may be a suitable vaccination strategy to combine advantages of both virus-neutralizing antibodies and CTLs.<\/jats:p>","DOI":"10.1084\/jem.187.4.649","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:54Z","timestamp":1027702134000},"page":"649-654","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Induction of Protective Cytotoxic T Cell Responses in the Presence of High Titers of \u2009Virus-neutralizing Antibodies: Implications for Passive and Active Immunization"],"prefix":"10.1084","volume":"187","author":[{"given":"Peter","family":"Seiler","sequence":"first","affiliation":[{"name":"From the *Institute of Experimental Immunology, Department of Pathology, University of Z\u00fcrich, CH-8091 Z\u00fcrich, Switzerland; and the \u2021Heinrich Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Anne","family":"Br\u00fcndler","sequence":"additional","affiliation":[{"name":"From the *Institute of Experimental Immunology, Department of Pathology, University of Z\u00fcrich, CH-8091 Z\u00fcrich, Switzerland; and the \u2021Heinrich Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"From the *Institute of Experimental Immunology, Department of Pathology, University of Z\u00fcrich, CH-8091 Z\u00fcrich, Switzerland; and the \u2021Heinrich Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Weibel","sequence":"additional","affiliation":[{"name":"From the *Institute of Experimental Immunology, Department of Pathology, University of Z\u00fcrich, CH-8091 Z\u00fcrich, Switzerland; and the \u2021Heinrich Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bruns","sequence":"additional","affiliation":[{"name":"From the *Institute of Experimental Immunology, Department of Pathology, University of Z\u00fcrich, CH-8091 Z\u00fcrich, Switzerland; and the \u2021Heinrich Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Hengartner","sequence":"additional","affiliation":[{"name":"From the *Institute of Experimental Immunology, Department of Pathology, University of Z\u00fcrich, CH-8091 Z\u00fcrich, Switzerland; and the \u2021Heinrich Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[{"name":"From the *Institute of Experimental Immunology, Department of Pathology, University of Z\u00fcrich, CH-8091 Z\u00fcrich, Switzerland; and the \u2021Heinrich Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie an der Universit\u00e4t Hamburg, D-20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1998,2,16]]},"reference":[{"key":"2023072915280532300_B1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1126\/science.271.5247.324","article-title":"Toward an understanding of the correlates of protective immunity to HIV infection","volume":"271","author":"Haynes","year":"1996","journal-title":"Science"},{"key":"2023072915280532300_B2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-065X.1996.tb00915.x","article-title":"Human herpes viruses latent infection in the nervous system","volume":"152","author":"Steiner","year":"1996","journal-title":"Immunol Rev"},{"key":"2023072915280532300_B3","doi-asserted-by":"crossref","first-page":"6874","DOI":"10.1073\/pnas.94.13.6874","article-title":"A critical role for neutralizing-antibody\u2013producing B cells, CD4+T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers","volume":"94","author":"Planz","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072915280532300_B4","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1002\/eji.1830231229","article-title":"Enhancement of disease by neutralizing antiviral antibodies in the absence of primed antiviral cytotoxic T cells","volume":"23","author":"Battegay","year":"1993","journal-title":"Eur J Immunol"},{"key":"2023072915280532300_B5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1084\/jem.146.1.201","article-title":"Dengue viruses and mononuclear phagocytes. 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