{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:12:10Z","timestamp":1791205930125,"version":"4.1.0"},"reference-count":52,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,3,2]]},"abstract":"<jats:p>Microphthalmia (Mi) is a basic helix-loop-helix\u2013leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells, and bone development. Two dominant-negative mi alleles (mi\/mi and Mior\/Mior) in mice cause osteopetrosis. In contrast, osteopetrosis has not been observed in a number of recessive mi alleles, suggesting the existence of Mi protein partners important in osteoclast function. An osteopetrotic rat of unknown genetic defect (mib) has been described whose skeletal sclerosis improves dramatically with age and that is associated with pigmentation defects reminiscent of mouse mi alleles. Here we report that this rat strain harbors a large genomic deletion encompassing the 3\u2032 half of mi including most of the b-HLH-ZIP region. Osteoclasts from these animals lack Mi protein in contrast to wild-type rat, mouse, and human osteoclasts. Mi is not detectable in primary osteoblasts. In addition TFE3, a b-HLH-ZIP transcription factor related to Mi, was found to be expressed in osteoclasts, but not osteoblasts, and to coimmunoprecipitate with Mi. These results demonstrate the existence of members of a family of biochemically related transcription factors that may cooperate to play a central role in osteoclast function and possibly in age-related osteoclast homeostasis.<\/jats:p>","DOI":"10.1084\/jem.187.5.775","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"775-785","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":76,"title":["Age-resolving Osteopetrosis: A Rat Model Implicating Microphthalmia and the Related Transcription Factor TFE3"],"prefix":"10.1084","volume":"187","author":[{"given":"Katherine N.","family":"Weilbaecher","sequence":"first","affiliation":[{"name":"From the *Dana Farber Cancer Institute, Department of Pediatric Oncology, Harvard Medical School, Boston, Massachusetts 02115; and the \u2021Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L.","family":"Hershey","sequence":"additional","affiliation":[{"name":"From the *Dana Farber Cancer Institute, Department of Pediatric Oncology, Harvard Medical School, Boston, Massachusetts 02115; and the \u2021Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford M.","family":"Takemoto","sequence":"additional","affiliation":[{"name":"From the *Dana Farber Cancer Institute, Department of Pediatric Oncology, Harvard Medical School, Boston, Massachusetts 02115; and the \u2021Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Horstmann","sequence":"additional","affiliation":[{"name":"From the *Dana Farber Cancer Institute, Department of Pediatric Oncology, Harvard Medical School, Boston, Massachusetts 02115; and the \u2021Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Hemesath","sequence":"additional","affiliation":[{"name":"From the *Dana Farber Cancer Institute, Department of Pediatric Oncology, Harvard Medical School, Boston, Massachusetts 02115; and the \u2021Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Armen H.","family":"Tashjian","sequence":"additional","affiliation":[{"name":"From the *Dana Farber Cancer Institute, Department of Pediatric Oncology, Harvard Medical School, Boston, Massachusetts 02115; and the \u2021Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Fisher","sequence":"additional","affiliation":[{"name":"From the *Dana Farber Cancer Institute, Department of Pediatric Oncology, Harvard Medical School, Boston, Massachusetts 02115; and the \u2021Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 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