{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:29:27Z","timestamp":1792765767393,"version":"4.5.0"},"reference-count":51,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,7,1]]},"abstract":"<jats:p>A null mutation was prepared in the mouse for CD18, the \u03b22 subunit of leukocyte integrins. Homozygous CD18 null mice develop chronic dermatitis with extensive facial and submandibular erosions. The phenotype includes elevated neutrophil counts, increased immunoglobulin levels, lymphadenopathy, splenomegaly, and abundant plasma cells in skin, lymph nodes, gut, and kidney. Very few neutrophils were found in spontaneously occurring skin lesions or with an induced toxic dermatitis. Intravital microscopy in CD18 null mice revealed a lack of firm neutrophil attachment to venules in the cremaster muscle in response to N-formyl- methionyl-leucyl-phenylalanine. A severe defect in T cell proliferation was found in the CD18 null mice when T cell receptors were stimulated either by staphylococcal enterotoxin A or by major histocompatibility complex alloantigens demonstrating a greater role of CD11\/CD18 integrins in T cell responses than previously documented. The null mice are useful for delineating the functions of CD18 in vivo.<\/jats:p>","DOI":"10.1084\/jem.188.1.119","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"119-131","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":273,"title":["Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice"],"prefix":"10.1084","volume":"188","author":[{"given":"Karin","family":"Scharffetter-Kochanek","sequence":"first","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Lu","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Norman","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"van Nood","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flor","family":"Munoz","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Grabbe","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"McArthur","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"},{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon","family":"Kaplan","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Ley","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Wayne Smith","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Rich","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur L.","family":"Beaudet","sequence":"additional","affiliation":[{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; **Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908; and \u2020\u2020Department of Dermatology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"},{"name":"From the *Department of Molecular and Human Genetics, \u2021Department of Pediatrics, \u00a7Department of Microbiology and Immunology, \u2016Center for Comparative Medicine, Baylor College of Medicine, and \u00b6Howard Hughes Medical Institute, Houston, Texas 77030; 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