{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T05:18:00Z","timestamp":1794201480784,"version":"4.8.0"},"reference-count":62,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,7,1]]},"abstract":"<jats:p>Viral infections often induce potent CD8 T cell responses that play a key role in antiviral immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo apoptosis, leaving behind a stable number of memory cells. The relationship between the CD8 T cells that clear the acute viral infection and the long-lived CD8 memory pool remaining in the individual is not fully understood. To address this issue, we examined the T cell receptor (TCR) repertoire of virus-specific CD8 T cells in the mouse model of infection with lymphocytic choriomeningitis virus (LCMV) using three approaches: (a) in vivo quantitative TCR \u03b2 chain V segment and complementarity determining region 3 (CDR3) length repertoire analysis by spectratyping (immunoscope); (b) identification of LCMV-specific CD8 T cells with MHC class I tetramers containing viral peptide and costaining with TCR V\u03b2\u2013specific antibodies; and (c) functional TCR fingerprinting based on recognition of variant peptides. We compared the repertoire of CD8 T cells responding to acute primary and secondary LCMV infections, together with that of virus-specific memory T cells in immune mice. Our analysis showed that CD8 T cells from several V\u03b2 families participated in the anti-LCMV response directed to the dominant cytotoxic T lymphocyte (CTL) epitope (NP118\u2013126). However, the bulk (\u223c70%) of this CTL response was due to three privileged T cell populations systematically expanding during LCMV infection. Approximately 30% of the response consisted of V\u03b210+ CD8 T cells with a \u03b2 chain CDR3 length of nine amino acids, and 40% consisted of V\u03b28.1+ (\u03b2 CDR3 = eight amino acids) and V\u03b28.2+ cells (\u03b2 CDR3 = six amino acids). Finally, we showed that the TCR repertoire of the primary antiviral CD8 T cell response was similar both structurally and functionally to that of the memory pool and the secondary CD8 T cell effectors. These results suggest a stochastic selection of memory cells from the pool of CD8 T cells activated during primary infection.<\/jats:p>","DOI":"10.1084\/jem.188.1.71","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"71-82","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":153,"title":["Conserved T Cell Receptor Repertoire in Primary and Memory CD8 T Cell Responses to an Acute Viral Infection"],"prefix":"10.1084","volume":"188","author":[{"given":"David J.D.","family":"Sourdive","sequence":"first","affiliation":[{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"},{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"},{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja","family":"Murali-Krishna","sequence":"additional","affiliation":[{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"},{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Altman","sequence":"additional","affiliation":[{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"},{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan J.","family":"Zajac","sequence":"additional","affiliation":[{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"},{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason K.","family":"Whitmire","sequence":"additional","affiliation":[{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"},{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Pannetier","sequence":"additional","affiliation":[{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"},{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Kourilsky","sequence":"additional","affiliation":[{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Evavold","sequence":"additional","affiliation":[{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"},{"name":"From the *Emory Vaccine Center, Rollins Research Center, and the \u2021Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322; the \u00a7Centre d'Etudes du Bouchet, 91710 Vert-le-Petit, France; the \u2016Unit\u00e9 de Biologie Mol\u00e9culaire du G\u00e8ne, Institut Pasteur, 75724 Paris cedex 15, France; and \u00b6Epimmune, San Diego, California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"key":"2023072508082939900_B1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1126\/science.272.5258.54","article-title":"Immunological memory and protective immunity: understanding their relation","volume":"272","author":"Ahmed","year":"1996","journal-title":"Science"},{"key":"2023072508082939900_B2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-065X.1988.tb00736.x","article-title":"Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene families","volume":"101","author":"Wilson","year":"1988","journal-title":"Immunol Rev"},{"key":"2023072508082939900_B3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.bi.59.070190.002355","article-title":"T cell receptor gene diversity and 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vivo","volume":"268","author":"McHeyzer-Williams","year":"1995","journal-title":"Science"},{"key":"2023072508082939900_B10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1074-7613(00)80297-6","article-title":"Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones","volume":"4","author":"Maryanski","year":"1996","journal-title":"Immunity"},{"key":"2023072508082939900_B11","doi-asserted-by":"crossref","first-page":"8987","DOI":"10.1073\/pnas.88.20.8987","article-title":"Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide","volume":"88","author":"Moss","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072508082939900_B12","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1128\/jvi.70.11.7569-7579.1996","article-title":"The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL","volume":"70","author":"Wills","year":"1996","journal-title":"J Virol"},{"key":"2023072508082939900_B13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0168-8278(97)80408-4","article-title":"Analysis of T-cell receptor Vbeta repertoire in liver-infiltrating lymphocytes in chronic hepatitis C","volume":"26","author":"Kashii","year":"1997","journal-title":"J Hepatol"},{"key":"2023072508082939900_B14","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1128\/jvi.66.6.3913-3917.1992","article-title":"Predominant use of a T-cell receptor V beta gene family in simian immunodeficiency virus Gag-specific cytotoxic T lymphocytes in a rhesus monkey","volume":"66","author":"Chen","year":"1992","journal-title":"J 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