{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:25:18Z","timestamp":1791289518415,"version":"4.3.0"},"reference-count":53,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,11,16]]},"abstract":"<jats:p>The development of T cell\u2013mediated autoimmune diseases hinges on the balance between effector and regulatory mechanisms. Using two transgenic mouse lines expressing identical myelin basic protein (MBP)\u2013specific T cell receptor (TCR) genes, we have previously shown that mice bearing exclusively MBP-specific T cells (designated T\/R\u2212) spontaneously develop experimental autoimmune encephalomyelitis (EAE), whereas mice bearing MBP-specific T cells as well as other lymphocytes (designated T\/R+) did not. Here we demonstrate that T\/R\u2212 mice can be protected from EAE by the early transfer of total splenocytes or purified CD4+ T cells from normal donors. Moreover, whereas T\/R+ mice crossed with B cell\u2013deficient, \u03b3\/\u03b4 T cell\u2013deficient, or major histocompatibility complex class I\u2013deficient mice did not develop EAE spontaneously, T\/R+ mice crossed with TCR-\u03b1 and -\u03b2 knockout mice developed EAE with the same incidence and severity as T\/R\u2212 mice. In addition, MBP-specific transgenic mice that lack only endogenous TCR-\u03b1 chains developed EAE with high incidence but reduced severity. Surprisingly, two-thirds of MBP-specific transgenic mice lacking only endogenous TCR-\u03b2 chains also developed EAE, suggesting that in T\/R+ mice, cells with high protective activity escape TCR-\u03b2 chain allelic exclusion. Our study identifies CD4+ T cells bearing endogenous \u03b1 and \u03b2 TCR chains as the lymphocytes that prevent spontaneous EAE in T\/R+ mice.<\/jats:p>","DOI":"10.1084\/jem.188.10.1883","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1883-1894","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":236,"title":["Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein\u2013specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis"],"prefix":"10.1084","volume":"188","author":[{"given":"Danyvid","family":"Olivares-Villag\u00f3mez","sequence":"first","affiliation":[{"name":"From the *Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and the Department of Pathology, and the \u2021\u2009Sackler Institute of Graduate Biomedical Sciences, New York University Medical Center, New York 10016"},{"name":"From the *Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and the Department of Pathology, and the \u2021\u2009Sackler Institute of Graduate Biomedical Sciences, New York University Medical Center, New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Wang","sequence":"additional","affiliation":[{"name":"From the *Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and the Department of Pathology, and the \u2021\u2009Sackler Institute of Graduate Biomedical Sciences, New York University Medical Center, New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Lafaille","sequence":"additional","affiliation":[{"name":"From the *Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and the Department of Pathology, and the \u2021\u2009Sackler Institute of Graduate Biomedical Sciences, New York University Medical Center, New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1998,11,16]]},"reference":[{"key":"2023072508060998600_B1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/0952-7915(92)90053-H","article-title":"T-cell subsets in autoimmunity","volume":"4","author":"Mason","year":"1992","journal-title":"Curr Opin Immunol"},{"key":"2023072508060998600_B2","doi-asserted-by":"crossref","first-page":"918","DOI":"10.4049\/jimmunol.129.3.918","article-title":"Experimental autoimmune encephalomyelitis (EAE) in genetically resistant rats: PVG rats resist active induction of EAE but are susceptible to and can generate EAE effector T cell lines","volume":"129","author":"Ben-Nun","year":"1982","journal-title":"J Immunol"},{"key":"2023072508060998600_B3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1986.tb01161.x","article-title":"Regulation of autoimmune disease physiological and therapeutic","volume":"94","author":"Cohen","year":"1986","journal-title":"Immunol Rev"},{"key":"2023072508060998600_B4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1084\/jem.177.3.627","article-title":"Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. 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