{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:23:22Z","timestamp":1791559402261,"version":"4.3.4"},"reference-count":55,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,8,17]]},"abstract":"<jats:p>The germinal center (GC) is an anatomic compartment found in peripheral lymphoid organs, wherein B cells undergo clonal expansion, somatic mutation, switch recombination, and reactivate immunoglobulin gene V(D)J recombination. As a result of somatic mutation, some GC B cells develop higher affinity antibodies, whereas others suffer mutations that decrease affinity, and still others may become self-reactive. It has been proposed that secondary V(D)J rearrangements in GCs might rescue B cells whose receptors are damaged by somatic mutations. Here we present evidence that mature human tonsil B cells coexpress conventional light chains and recombination associated genes, and that they extinguish recombination activating gene and terminal deoxynucleotidyl transferase expression when their receptors are cross-linked. Thus, the response of the recombinase to receptor engagement in peripheral B cells is the opposite of the response in developing B cells to the same stimulus. These observations suggest that receptor revision is a mechanism for receptor diversification that is turned off when antigen receptors are cross-linked by the cognate antigen.<\/jats:p>","DOI":"10.1084\/jem.188.4.765","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"765-772","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":108,"title":["Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells"],"prefix":"10.1084","volume":"188","author":[{"given":"Eric","family":"Meffre","sequence":"first","affiliation":[{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"},{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotini","family":"Papavasiliou","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cohen","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odette","family":"de Bouteiller","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Bell","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Karasuyama","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Schiff","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Banchereau","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel C.","family":"Nussenzweig","sequence":"additional","affiliation":[{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"},{"name":"From the *Laboratory of Molecular Immunology and the \u2021Howard Hughes Medical Institute, The Rockefeller University, New York 10021-6399; \u00a7Schering-Plough Laboratory for Immunobiology, Dardilly 69571, France; the \u2016Baylor Institute for Immunology Research, Sammons Cancer Center, Dallas, Texas 75246; the \u00b6Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113, Japan; the **Centre d'Immunologie de Marseille-Luminy, 13288 Marseille cedex 09, France; and the \u2020\u2020DNAX Research Institute, Palo Alto, California 94304-1104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1998,8,17]]},"reference":[{"key":"2023072508163175700_B1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/302575a0","article-title":"Somatic generation of antibody diversity","volume":"302","author":"Tonegawa","year":"1983","journal-title":"Nature"},{"key":"2023072508163175700_B2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0959-437X(96)80090-6","article-title":"Developmental regulation of V(D)J recombination and lymphocyte differentiation","volume":"6","author":"Willerford","year":"1996","journal-title":"Curr Opin Genet 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