{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:10:30Z","timestamp":1790856630425,"version":"4.1.0"},"reference-count":28,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,9,21]]},"abstract":"<jats:p>Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific T cells ex vivo, we observed high frequencies of circulating MelanA-specific, A*0201-restricted cytotoxic T lymphocytes (A2\u2013MelanA tetramer+ CTLs) in seven of nine HLA-A*0201\u2013positive individuals with vitiligo. Isolated A2\u2013MelanA tetramer+ CTLs were able to lyse A*0201-matched melanoma cells in vitro and their frequency ex vivo correlated with extent of disease. In contrast, no A2\u2013MelanA tetramer+ CTL could be identified ex vivo in all four A*0201-negative vitiligo patients or five of six A*0201-positive asymptomatic controls. Finally, we observed that the A2\u2013MelanA tetramer+ CTLs isolated from vitiligo patients expressed high levels of the skin homing receptor, cutaneous lymphocyte-associated antigen, which was absent from the CTLs seen in the single A*0201-positive normal control. These data are consistent with a role of skin-homing autoreactive melanocyte-specific CTLs in causing the destruction of melanocytes seen in autoimmune vitiligo. Lack of homing receptors on the surface of autoreactive CTLs could be a mechanism to control peripheral tolerance in vivo.<\/jats:p>","DOI":"10.1084\/jem.188.6.1203","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1203-1208","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":358,"title":["High Frequency of Skin-homing Melanocyte-specific Cytotoxic T Lymphocytes in Autoimmune Vitiligo"],"prefix":"10.1084","volume":"188","author":[{"given":"Graham S.","family":"Ogg","sequence":"first","affiliation":[{"name":"From the *Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, Oxford, OX3 9DS, United Kingdom; and the \u2021Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, 1011 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rod Dunbar","sequence":"additional","affiliation":[{"name":"From the *Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, Oxford, OX3 9DS, United Kingdom; and the \u2021Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, 1011 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Romero","sequence":"additional","affiliation":[{"name":"From the *Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, Oxford, OX3 9DS, United Kingdom; and the \u2021Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, 1011 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Li","family":"Chen","sequence":"additional","affiliation":[{"name":"From the *Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, Oxford, OX3 9DS, United Kingdom; and the \u2021Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, 1011 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Cerundolo","sequence":"additional","affiliation":[{"name":"From the *Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, Oxford, OX3 9DS, United Kingdom; and the \u2021Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, 1011 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1998,9,21]]},"reference":[{"key":"2023072508225189400_B1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0140-6736(94)91709-4","article-title":"The role of tyrosinase in autoimmune vitiligo","volume":"344","author":"Song","year":"1994","journal-title":"Lancet"},{"key":"2023072508225189400_B2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1046\/j.1365-2249.1997.4781381.x","article-title":"Immunoprecipitation of melanogenic 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