{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:34:17Z","timestamp":1790969657185,"version":"4.1.0"},"reference-count":37,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,11,2]]},"abstract":"<jats:p>Mast cells have long been believed to be the central effector cells in the development of immunoglobulin (Ig)E-dependent anaphylaxis. In this study, we investigated the role of mast cells in IgE-dependent hapten-induced active fatal anaphylaxis using mast cell\u2013deficient WBB6F1- W\/Wv (W\/Wv) and congenic normal (+\/+) mice. Although a 5-min delay in shock signs and death were observed in W\/Wv mice, 100% fatal reactions to penicillin V (Pen V) occurred in both +\/+ and W\/Wv mice. Administration of monoclonal anti\u2013IL-4 antibody completely prevented the fatal reactions, and the effect of anti\u2013IL-4 was associated with its suppressive activity on Pen V\u2013specific serum levels of IgE, but not IgG. The platelet-activating factor (PAF) antagonist, BN 50739, completely prevented the fatal reactions in both strains of mice. Our kinetic study revealed, in contrast to no elevation of plasma histamine level in W\/Wv mice, high levels of PAF in the circulation after challenge in both +\/+ and W\/Wv mice, albeit to a lesser degree in the latter case. These data indicate that cells other than mast cells are sufficient to induce an IgE-dependent active fatal anaphylaxis by elaborating PAF, which is the critical mediator for fatal murine anaphylaxis.<\/jats:p>","DOI":"10.1084\/jem.188.9.1587","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1587-1592","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Immunoglobulin E\u2013dependent Active Fatal Anaphylaxis in Mast Cell\u2013deficient Mice"],"prefix":"10.1084","volume":"188","author":[{"given":"Il Hwan","family":"Choi","sequence":"first","affiliation":[{"name":"From the *Department of Immunology and Institute for Medical Science, and the \u2021Department of Anatomy, Chonbuk National University Medical School, Chonju, Chonbuk, 561-182, Republic of Korea; and the \u00a7Department of Microbiology and Hormone Research Center, College of Natural Science, Chonnam National University, Kwangju, Chonnam, 500-757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Min","family":"Shin","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology and Institute for Medical Science, and the \u2021Department of Anatomy, Chonbuk National University Medical School, Chonju, Chonbuk, 561-182, Republic of Korea; and the \u00a7Department of Microbiology and Hormone Research Center, College of Natural Science, Chonnam National University, Kwangju, Chonnam, 500-757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Seung","family":"Park","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology and Institute for Medical Science, and the \u2021Department of Anatomy, Chonbuk National University Medical School, Chonju, Chonbuk, 561-182, Republic of Korea; and the \u00a7Department of Microbiology and Hormone Research Center, College of Natural Science, Chonnam National University, Kwangju, Chonnam, 500-757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moo Sam","family":"Lee","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology and Institute for Medical Science, and the \u2021Department of Anatomy, Chonbuk National University Medical School, Chonju, Chonbuk, 561-182, Republic of Korea; and the \u00a7Department of Microbiology and Hormone Research Center, College of Natural Science, Chonnam National University, Kwangju, Chonnam, 500-757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eue Hyeog","family":"Han","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology and Institute for Medical Science, and the \u2021Department of Anatomy, Chonbuk National University Medical School, Chonju, Chonbuk, 561-182, Republic of Korea; and the \u00a7Department of Microbiology and Hormone Research Center, College of Natural Science, Chonnam National University, Kwangju, Chonnam, 500-757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ok Hee","family":"Chai","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology and Institute for Medical Science, and the \u2021Department of Anatomy, Chonbuk National University Medical School, Chonju, Chonbuk, 561-182, Republic of Korea; and the \u00a7Department of Microbiology and Hormone Research Center, College of Natural Science, Chonnam National University, Kwangju, Chonnam, 500-757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun Young","family":"Im","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology and Institute for Medical Science, and the \u2021Department of Anatomy, Chonbuk National University Medical School, Chonju, Chonbuk, 561-182, Republic of Korea; and the \u00a7Department of Microbiology and Hormone Research Center, College of Natural Science, Chonnam National University, Kwangju, Chonnam, 500-757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai\u2009 You","family":"Ha","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology and Institute for Medical Science, and the \u2021Department of Anatomy, Chonbuk National University Medical School, Chonju, Chonbuk, 561-182, Republic of Korea; and the \u00a7Department of Microbiology and Hormone Research Center, College of Natural Science, Chonnam National University, Kwangju, Chonnam, 500-757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern-Ku","family":"Lee","sequence":"additional","affiliation":[{"name":"From the *Department of Immunology and Institute for Medical Science, and the \u2021Department of Anatomy, Chonbuk National University Medical School, Chonju, Chonbuk, 561-182, Republic of Korea; and the 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