{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:06:03Z","timestamp":1790849163437,"version":"4.1.0"},"reference-count":46,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,11,2]]},"abstract":"<jats:p>A basic principle of immunology is that prior immunity results in complete protection against a homologous agent. In this study, we show that memory T cells specific to unrelated viruses may alter the host's primary immune response to a second virus. Studies with a panel of heterologous viruses, including lymphocytic choriomeningitis (LCMV), Pichinde (PV), vaccinia (VV), and murine cytomegalo (MCMV) viruses showed that prior immunity with one of these viruses in many cases enhanced clearance of a second unrelated virus early in infection. Such protective immunity was common, but it depended on the virus sequence and was not necessarily reciprocal. Cell transfer studies showed that both CD4 and CD8 T cell populations from LCMV-immune mice were required to transfer protective immunity to naive hosts challenged with PV or VV. In the case of LCMV-immune versus naive mice challenged with VV, there was an enhanced early recruitment of memory phenotype interferon (IFN) \u03b3\u2013secreting CD4+ and CD8+ cells into the peritoneal cavity and increased IFN-\u03b3 levels in this initial site of virus replication. Studies with IFN-\u03b3 receptor knockout mice confirmed a role for IFN-\u03b3 in mediating the protective effect by LCMV-immune T cell populations when mice were challenged with VV but not PV. In some virus sequences memory cell populations, although clearing the challenge virus more rapidly, elicited enhanced IFN-\u03b3\u2013dependent immunopathogenesis in the form of acute fatty necrosis. These results indicate that how a host responds to an infectious agent is a function of its history of previous infections and their influence on the memory T cell pool.<\/jats:p>","DOI":"10.1084\/jem.188.9.1705","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1705-1715","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":199,"title":["Protective Heterologous Antiviral Immunity and Enhanced Immunopathogenesis Mediated by Memory T Cell Populations"],"prefix":"10.1084","volume":"188","author":[{"given":"Liisa K.","family":"Selin","sequence":"first","affiliation":[{"name":"From the Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Varga","sequence":"additional","affiliation":[{"name":"From the Department of 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