{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:22:57Z","timestamp":1790511777227,"version":"4.1.0"},"reference-count":90,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,11,2]]},"abstract":"<jats:p>The molecular mechanisms that contribute to an eosinophil-rich airway inflammation in asthma are unclear. A predominantly T helper 2 (Th2)-type cell response has been documented in allergic asthma. Here we show that mice deficient in the p50 subunit of nuclear factor (NF)- \u03baB are incapable of mounting eosinophilic airway inflammation compared with wild-type mice. This deficiency was not due to a block in T cell priming or proliferation in the p50\u2212\/\u2212 mice, nor was it due to a defect in the expression of the cell adhesion molecules VCAM-1 and ICAM-1 that are required for the extravasation of eosinophils into the airways. The major defects in the p50\u2212\/\u2212 mice were the lack of production of the Th2 cytokine interleukin 5 and the chemokine eotaxin, which are crucial for proliferation and for differentiation and recruitment, respectively, of eosinophils into the asthmatic airway. Additionally, the p50\u2212\/\u2212 mice were deficient in the production of the chemokines macrophage inflammatory protein (MIP)-1\u03b1 and MIP-1\u03b2 that have been implicated in T cell recruitment to sites of inflammation. These results demonstrate a crucial role for NF-\u03baB in vivo in the expression of important molecules that have been implicated in the pathogenesis of asthma.<\/jats:p>","DOI":"10.1084\/jem.188.9.1739","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1739-1750","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":243,"title":["Essential Role of Nuclear Factor \u03baB in the Induction of Eosinophilia in Allergic Airway Inflammation"],"prefix":"10.1084","volume":"188","author":[{"given":"Liyan","family":"Yang","sequence":"first","affiliation":[{"name":"From the *Department of Internal Medicine, Pulmonary and Critical Care Section, the \u2021Section of Immunobiology, and the \u00a7Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Cohn","sequence":"additional","affiliation":[{"name":"From the *Department of Internal Medicine, Pulmonary and Critical Care Section, the \u2021Section of Immunobiology, and the \u00a7Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520"},{"name":"From the *Department of Internal Medicine, Pulmonary and Critical Care Section, the \u2021Section of Immunobiology, and the \u00a7Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the *Department of Internal Medicine, Pulmonary and Critical Care Section, the \u2021Section of Immunobiology, and the \u00a7Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Homer","sequence":"additional","affiliation":[{"name":"From the *Department of Internal Medicine, Pulmonary and Critical Care Section, the \u2021Section of Immunobiology, and the \u00a7Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Ray","sequence":"additional","affiliation":[{"name":"From the *Department of Internal Medicine, Pulmonary and Critical Care Section, the \u2021Section of Immunobiology, and the \u00a7Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabir","family":"Ray","sequence":"additional","affiliation":[{"name":"From the *Department of Internal Medicine, Pulmonary and Critical Care Section, the \u2021Section of Immunobiology, and the \u00a7Department 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