{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:03:57Z","timestamp":1770703437469,"version":"3.49.0"},"reference-count":67,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,1,4]]},"abstract":"<jats:p>To investigate the influence of endogenous peptides on the developmental processes that occur during thymocyte selection, we have used monoclonal antibodies that preferentially recognize the major histocompatibility complex (MHC) molecule I-Ek when it is bound to the moth cytochrome c peptide (88\u2013103). One of these antibodies (G35) specifically blocks the positive selection of transgenic thymocytes expressing a T cell receptor that is reactive to this peptide\u2013 MHC complex. Furthermore, G35 does not block the differentiation of transgenic T cells bearing receptors for a different I-Ek\u2013peptide complex. This antibody recognizes a subset of endogenous I-Ek\u2013peptide complexes found on a significant fraction of thymic antigen-presenting cells, including cortical and medullary epithelial cells. The sensitivity of G35 to minor alterations in peptide sequence suggests that the thymic peptide\u2013MHC complexes that mediate the positive selection of a particular class II MHC\u2013restricted thymocyte are structurally related to the complexes that can activate it in the periphery.<\/jats:p>","DOI":"10.1084\/jem.189.1.13","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"13-24","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["A T Cell Receptor\u2013specific Blockade of Positive Selection"],"prefix":"10.1084","volume":"189","author":[{"given":"Kristin K.","family":"Baldwin","sequence":"first","affiliation":[{"name":"From the *Howard Hughes Medical Institute, and the Department of Microbiology and Immunology, Stanford University, Stanford, California 94305; the \u2021Department of Biological Structure and Department of Immunology, School of Medicine, University of Washington, Seattle, Washington 98195; and the \u00a7Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DU, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A.","family":"Reay","sequence":"additional","affiliation":[{"name":"From the *Howard Hughes Medical Institute, and the Department of Microbiology and Immunology, Stanford University, Stanford, California 94305; the \u2021Department of Biological Structure and Department of Immunology, School of Medicine, University of Washington, Seattle, Washington 98195; and the \u00a7Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DU, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawren","family":"Wu","sequence":"additional","affiliation":[{"name":"From the *Howard Hughes Medical Institute, and the Department of Microbiology and Immunology, Stanford University, Stanford, California 94305; the \u2021Department of Biological Structure and Department of Immunology, School of Medicine, University of Washington, Seattle, Washington 98195; and the \u00a7Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DU, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Farr","sequence":"additional","affiliation":[{"name":"From the *Howard Hughes Medical Institute, and the Department of Microbiology and Immunology, Stanford University, Stanford, California 94305; the \u2021Department of Biological Structure and Department of Immunology, School of Medicine, University of Washington, Seattle, Washington 98195; and the \u00a7Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DU, United 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