{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:12:29Z","timestamp":1791299549146,"version":"4.1.0"},"reference-count":41,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,5,17]]},"abstract":"<jats:p>The requirement of \u03b27 integrins for lymphocyte migration was examined during an ongoing immune response in vivo. Transgenic mice (OT-I) expressing an ovalbumin-specific major histocompatibility complex class I\u2013restricted T cell receptor for antigen were rendered deficient in expression of all \u03b27 integrins or only the \u03b1E\u03b27 integrin. To quantitate the relative use of \u03b27 integrins in migration in vivo, equal numbers of OT-I and OT-I-\u03b27\u2212\/\u2212 or OT-I-\u03b1E\u2212\/\u2212 lymph node (LN) cells were adoptively transferred to normal mice. Although OT-I-\u03b27\u2212\/\u2212 LN cells migrated to mesenteric LN and peripheral LN as well as wild-type cells, \u03b27 integrins were required for naive CD8 T cell and B cell migration to Peyer's patch. After infection with a recombinant virus (vesicular stomatitis virus) encoding ovalbumin, \u03b27 integrins became critical for migration of activated CD8 T cells to the mesenteric LN and Peyer's patch. Naive CD8 T cells did not enter the lamina propria or the intestinal epithelium, and the majority of migration of activated CD8 T cells to the small and large intestinal mucosa, including the epithelium, was \u03b27 integrin\u2013mediated. The \u03b1E\u03b27 integrin appeared to play no role in migration during a primary CD8 T cell immune response in vivo. Furthermore, despite dramatic upregulation of \u03b1E\u03b27 by CD8 T cells after entry into the epithelium, long-term retention of intestinal intraepithelial lymphocytes was also \u03b1E\u03b27 independent.<\/jats:p>","DOI":"10.1084\/jem.189.10.1631","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1631-1638","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":186,"title":["The Role of \u03b27 Integrins in CD8 T Cell Trafficking During an Antiviral Immune Response"],"prefix":"10.1084","volume":"189","author":[{"given":"Leo","family":"Lefran\u00e7ois","sequence":"first","affiliation":[{"name":"From the *Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, Connecticut 06037; the \u2021Lymphocyte Biology Section, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; and the \u00a7Institute for Genetics, University of Cologne, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Parker","sequence":"additional","affiliation":[{"name":"From the *Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, Connecticut 06037; the \u2021Lymphocyte Biology Section, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; and the \u00a7Institute for Genetics, University of Cologne, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Olson","sequence":"additional","affiliation":[{"name":"From the *Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, Connecticut 06037; the \u2021Lymphocyte Biology Section, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; and the \u00a7Institute for Genetics, University of Cologne, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Muller","sequence":"additional","affiliation":[{"name":"From the *Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, Connecticut 06037; the \u2021Lymphocyte Biology Section, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; and the \u00a7Institute for Genetics, University of Cologne, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Wagner","sequence":"additional","affiliation":[{"name":"From the *Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, Connecticut 06037; the \u2021Lymphocyte Biology Section, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; and the \u00a7Institute for Genetics, University of Cologne, 50937 Cologne, 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