{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:04:08Z","timestamp":1791223448900,"version":"4.1.0"},"reference-count":55,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,6,21]]},"abstract":"<jats:p>Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. The proinflammatory cytokine interleukin (IL)-1\u03b2 and its antagonist, IL-1Ra (IL-1 receptor agonist), are strongly induced by M. tuberculosis and are encoded by polymorphic genes. The induction of both IL-1Ra mRNA and secreted protein by M. tuberculosis in IL-1Ra allele A2\u2013positive (IL-1Ra A2+) healthy subjects was 1.9-fold higher than in IL-1Ra A2\u2212 subjects. The M. tuberculosis\u2013induced expression of mRNA for IL-1\u03b2 was higher in subjects of the IL-1\u03b2 (+3953) A1+ haplotype (P = 0.04). The molar ratio of IL-1Ra\/IL-1\u03b2 induced by M. tuberculosis was markedly higher in IL-1Ra A2+ individuals (P &amp;lt; 0.05), with minor overlap between the groups, reflecting linkage between the IL-1Ra A2 and IL-1\u03b2 (+3953) A2 alleles. In M. tuberculosis\u2013stimulated peripheral blood mononuclear cells, the addition of IL-4 increased IL-1Ra secretion, whereas interferon \u03b3 increased and IL-10 decreased IL-1\u03b2 production, indicative of a differential influence on the IL-1Ra\/IL-1\u03b2 ratio by cytokines. In a study of 114 healthy purified protein derivative\u2013reactive subjects and 89 patients with tuberculosis, the frequency of allelic variants at two positions (\u2212511 and +3953) in the IL-1\u03b2 and IL-1Ra genes did not differ between the groups. However, the proinflammatory IL-1Ra A2\u2212\/IL-1\u03b2 (+3953) A1+ haplotype was unevenly distributed, being more common in patients with tuberculous pleurisy (92%) in comparison with healthy M. tuberculosis\u2013sensitized control subjects or patients with other disease forms (57%, P = 0.028 and 56%, P = 0.024, respectively). Furthermore, the IL-1Ra A2+ haplotype was associated with a reduced Mantoux response to purified protein derivative of M. tuberculosis: 60% of tuberculin-nonreactive patients were of this type. Thus, the polymorphism at the IL-1 locus influences the cytokine response and may be a determinant of \u2009delayed-type hypersensitivity and disease expression in human tuberculosis.<\/jats:p>","DOI":"10.1084\/jem.189.12.1863","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"1863-1874","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":225,"title":["Influence of Polymorphism in the Genes for the Interleukin (IL)-1 Receptor Antagonist and IL-1\u03b2 on Tuberculosis"],"prefix":"10.1084","volume":"189","author":[{"given":"Robert J.","family":"Wilkinson","sequence":"first","affiliation":[{"name":"From the *Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984; and the \u2021Wellcome Center for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, United Kingdom"},{"name":"From the *Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984; and the \u2021Wellcome Center for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punita","family":"Patel","sequence":"additional","affiliation":[{"name":"From the *Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984; and the \u2021Wellcome Center for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Llewelyn","sequence":"additional","affiliation":[{"name":"From the *Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984; and the \u2021Wellcome Center for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina S.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"From the *Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984; and the \u2021Wellcome Center for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Pasvol","sequence":"additional","affiliation":[{"name":"From the *Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984; and the \u2021Wellcome Center for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Snounou","sequence":"additional","affiliation":[{"name":"From the *Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984; and the \u2021Wellcome Center for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Davidson","sequence":"additional","affiliation":[{"name":"From the *Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984; and the \u2021Wellcome Center for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Toossi","sequence":"additional","affiliation":[{"name":"From the *Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984; and the \u2021Wellcome Center for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1999,6,21]]},"reference":[{"key":"2023072508224228600_B1","doi-asserted-by":"crossref","first-page":"9869","DOI":"10.1073\/pnas.94.18.9869","article-title":"Restricted structural gene polymorphism in the Mycobacterium tuberculosiscomplex indicates evolutionarily recent global dissemination","volume":"94","author":"Sreevastsan","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072508224228600_B2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.7326\/0003-4819-116-11-937","article-title":"Genetics and resistance to tuberculosis: could resistance be enhanced by genetic engineering?","volume":"116","author":"Stead","year":"1992","journal-title":"Ann Intern Med"},{"key":"2023072508224228600_B3","doi-asserted-by":"crossref","first-page":"13227","DOI":"10.1073\/pnas.94.24.13227","article-title":"An epidemic of tuberculosis with a high rate of tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon","volume":"94","author":"Sousa","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072508224228600_B4","first-page":"621","article-title":"Tuberculosis in twins: a re-analysis of the Prophit survey","volume":"117","author":"Comstock","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"2023072508224228600_B5","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1056\/NEJM199612263352602","article-title":"A mutation in the interferon-\u03b3 receptor gene and susceptibility to mycobacterial infection","volume":"335","author":"Newport","year":"1996","journal-title":"N Engl J Med"},{"key":"2023072508224228600_B6","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1056\/NEJM199612263352604","article-title":"Interferon-gamma-receptor deficiency in an infant with fatal Bacille Calmette-Gu\u00e9rin infection","volume":"335","author":"Jouanguy","year":"1996","journal-title":"N Engl J Med"},{"key":"2023072508224228600_B7","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1172\/JCI2901","article-title":"Mutation in the signal-transducing chain of the interferon \u03b3 receptor and susceptibility to mycobacterial infection","volume":"101","author":"Dorman","year":"1998","journal-title":"J Clin Invest"},{"key":"2023072508224228600_B8","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1126\/science.280.5368.1435","article-title":"Severe mycobacterial and salmonella infections in interleukin-12 receptor-deficient patients","volume":"280","author":"Jong","year":"1998","journal-title":"Science"},{"key":"2023072508224228600_B9","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1126\/science.280.5368.1432","article-title":"Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency","volume":"280","author":"Altare","year":"1998","journal-title":"Science"},{"key":"2023072508224228600_B10","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1172\/JCI4950","article-title":"Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis\u2013disseminated infection","volume":"102","author":"Altare","year":"1998","journal-title":"J Clin Invest"},{"key":"2023072508224228600_B11","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJM199803053381002","article-title":"Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans","volume":"338","author":"Bellamy","year":"1998","journal-title":"N Engl J Med"},{"key":"2023072508224228600_B12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1086\/314614","article-title":"Tuberculosis and chronic Hepatitis B virus infection in Africans and variation in the vitamin D receptor gene","volume":"179","author":"Bellamy","year":"1999","journal-title":"J Infect Dis"},{"key":"2023072508224228600_B13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1056\/NEJM199803053381001","article-title":"An outbreak involving extensive transmission of a virulent strain of Mycobacterium tuberculosis.","volume":"338","author":"Valway","year":"1998","journal-title":"N Engl J Med"},{"key":"2023072508224228600_B14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.immunol.16.1.593","article-title":"Immunogenetics of human infectious diseases","volume":"16","author":"Hill","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"2023072508224228600_B15","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jlb.63.4.440","article-title":"Nonspecific and immune-specific up-regulation of cytokines in rabbit dermal tuberculous (BCG) lesions","volume":"63","author":"Sugisaki","year":"1998","journal-title":"J Leukoc Biol"},{"key":"2023072508224228600_B16","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0092-8674(89)90676-4","article-title":"The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection","volume":"56","author":"Kindler","year":"1989","journal-title":"Cell"},{"key":"2023072508224228600_B17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.immunol.16.1.27","article-title":"Interleukin 1 receptor antagonist: role in biology","volume":"16","author":"Arend","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"2023072508224228600_B18","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/hmg\/1.6.450","article-title":"Single base polymorphism at \u2212511 in the human interleukin-1\u03b2 gene","volume":"1","author":"di Giovine","year":"1993","journal-title":"Hum Mol Genet"},{"key":"2023072508224228600_B19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1365-2362.1992.tb01480.x","article-title":"A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro","volume":"22","author":"Pociot","year":"1992","journal-title":"Eur J Clin Invest"},{"key":"2023072508224228600_B20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/BF00217368","article-title":"Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat","volume":"91","author":"Tarlow","year":"1993","journal-title":"Hum Genet"},{"key":"2023072508224228600_B21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2249.1995.tb05549.x","article-title":"Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism","volume":"99","author":"Danis","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"2023072508224228600_B22","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2598::AID-IMMU2598>3.0.CO;2-K","article-title":"IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1\u03b2 genes","volume":"28","author":"Hurme","year":"1998","journal-title":"Eur J Immunol"},{"key":"2023072508224228600_B23","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1164\/ajrccm.157.4.9709126","article-title":"Tumor necrosis factor and interleukin-1 inhibitors as markers of disease activity of tuberculosis","volume":"157","author":"Juffermans","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"2023072508224228600_B24","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3109\/00365549409008634","article-title":"Cerebrospinal fluid interleukin-1 beta\/interleukin-1 receptor antagonist balance and tumor necrosis factor-alpha concentrations in tuberculous, viral and acute bacterial meningitis","volume":"26","author":"Akalin","year":"1994","journal-title":"Scand J Infect Dis"},{"key":"2023072508224228600_B25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/thx.53.3.176","article-title":"Geographical distribution of tuberculosis notifications in national surveys of England and Wales in 1988 and 1993: report of the public health laboratory service\/ British Thoracic Society\/Department of Health collaborative group","volume":"53","author":"Ormerod","year":"1998","journal-title":"Thorax"},{"key":"2023072508224228600_B26","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/infdis\/170.5.1229","article-title":"Enhancement of intracellular growth of \u2009Mycobacterium tuberculosisin human monocytes by transforming growth factor-beta 1","volume":"170","author":"Hirsch","year":"1994","journal-title":"J Infect Dis"},{"key":"2023072508224228600_B27","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.4049\/jimmunol.156.9.3461","article-title":"Decreased production of TGF-\u03b21 by human alveolar macrophages compared with blood monocytes","volume":"156","author":"Toossi","year":"1996","journal-title":"J Immunol"},{"key":"2023072508224228600_B28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-2776(08)60535-0","article-title":"Interleukin-1 receptor antagonist","volume":"54","author":"Arend","year":"1993","journal-title":"Adv Immunol"},{"key":"2023072508224228600_B29","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1073\/pnas.93.8.3193","article-title":"Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon gamma production","volume":"93","author":"Hirsch","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072508224228600_B30","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1073\/pnas.94.8.3926","article-title":"In vitro restoration of \u2009T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosisby natural inhibitors of transforming growth factor beta","volume":"94","author":"Hirsch","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072508224228600_B31","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1002\/eji.1830241242","article-title":"Induction by transforming growth factor-beta 1 of the interleukin-1 receptor antagonist and of its intracellular form in human polymorphonuclear cells","volume":"24","author":"Muzio","year":"1994","journal-title":"Eur J Immunol"},{"key":"2023072508224228600_B32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/1043-4666(93)90030-9","article-title":"Interleukin 1 receptor antagonist production in human monocytes is induced by IL-1 alpha, IL-3, IL-4 and GM-CSF","volume":"5","author":"Jenkins","year":"1993","journal-title":"Cytokines"},{"key":"2023072508224228600_B33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/eji.1830270125","article-title":"Human Th1 cells preferentially induce interleukin (IL)-1\u03b2 while Th2 cells induce IL-1 receptor antagonist production upon cell\/cell contact with monocytes","volume":"27","author":"Chizzolini","year":"1997","journal-title":"Eur J Immunol"},{"key":"2023072508224228600_B34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4049\/jimmunol.145.1.149","article-title":"Local production of tumor necrosis factor and IFN-\u03b3 in tuberculous pleuritis","volume":"145","author":"Barnes","year":"1990","journal-title":"J Immunol"},{"key":"2023072508224228600_B35","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.4049\/jimmunol.142.4.1114","article-title":"Compartmentalization of a CD4+T lymphocyte subpopulation in tuberculous pleuritis","volume":"142","author":"Barnes","year":"1989","journal-title":"J Immunol"},{"key":"2023072508224228600_B36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-3083.1998.00300.x","article-title":"Presence of the IL-1RA allele 2 (IL1RN*2)is associated with enhanced IL-1beta production in vitro","volume":"47","author":"Santtila","year":"1998","journal-title":"Scand J Immunol"},{"key":"2023072508224228600_B37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1128\/iai.62.2.457-461.1994","article-title":"Interleukin-1 is involved in mouse resistance to Mycobacterium avium.","volume":"62","author":"Denis","year":"1994","journal-title":"Infect Immun"},{"key":"2023072508224228600_B38","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/thx.51.12.1253","article-title":"Increased inflammatory cytokines and new collagen formation in cutaneous tuberculosis and sarcoidosis","volume":"51","author":"Marshall","year":"1996","journal-title":"Thorax"},{"key":"2023072508224228600_B39","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1172\/JCI117702","article-title":"Enhanced interleukin-8 release and gene expression in macrophages after exposure to Mycobacterium tuberculosisand its components","volume":"95","author":"Zhang","year":"1995","journal-title":"J Clin Invest"},{"key":"2023072508224228600_B40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0171-2985(11)80442-0","article-title":"BCG-induced granuloma formation in murine tissues","volume":"191","author":"Gordon","year":"1994","journal-title":"Immunobiology"},{"key":"2023072508224228600_B41","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.4049\/jimmunol.159.6.3034","article-title":"Cytokine patterns in tuberculous and sarcoid granulomas: correlations with histopathologic features of the granulomatous response","volume":"159","author":"Bergeron","year":"1997","journal-title":"J Immunol"},{"key":"2023072508224228600_B42","first-page":"392","article-title":"Differential regulation of Th1 and Th2 cells by p91-110 and p21-40 peptides of the 16 kDa \u03b1-crystallin antigen of Mycobacterium tuberculosis.","volume":"104","author":"Agrewala","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"2023072508224228600_B43","first-page":"171","article-title":"Th1\/Th2 profiles in tuberculosis based on proliferation and cytokine response of blood lymphocytes to mycobacterial antigens","volume":"81","author":"Surcel","year":"1994","journal-title":"Immunology"},{"key":"2023072508224228600_B44","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1086\/515336","article-title":"Peptide specific response to M. tuberculosis: clinical spectrum, compartmentalization, and effect of chemotherapy","volume":"178","author":"Wilkinson","year":"1998","journal-title":"J Infect Dis"},{"key":"2023072508224228600_B45","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1128\/iai.61.8.3482-3489.1993","article-title":"Cytokine production at the site of disease in human tuberculosis","volume":"61","author":"Barnes","year":"1993","journal-title":"Infect Immun"},{"key":"2023072508224228600_B46","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1128\/IAI.66.4.1666-1670.1998","article-title":"Adequate expression of protective immunity in the absence of granuloma formation in Mycobacterium tuberculosis- infected mice with a disruption in the intracellular adhesion molecule 1 gene","volume":"66","author":"Johnson","year":"1998","journal-title":"Infect Immun"},{"key":"2023072508224228600_B47"},{"key":"2023072508224228600_B48","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0962-8479(94)90043-4","article-title":"Tuberculin reactivity after newborn BCG immunisation in mono- and dizygotic twins","volume":"75","author":"Sepulveda","year":"1994","journal-title":"Tuber Lung Dis"},{"key":"2023072508224228600_B49","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1164\/ajrccm.149.3.8118628","article-title":"Evaluation for tuberculin reactivity in BCG immunised siblings","volume":"149","author":"Sepulveda","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2023072508224228600_B50","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3201\/eid0404.980409","article-title":"Genetic epidemiology of infectious diseases in humans: design of population based studies","volume":"4","author":"Abel","year":"1998","journal-title":"Emerg Infect Dis"},{"key":"2023072508224228600_B51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1054\/tuld.1998.0009","article-title":"Assessment of the interleukin 1 gene cluster and other candidate gene polymorphisms in host susceptibility to tuberculosis","volume":"79","author":"Bellamy","year":"1998","journal-title":"Tuberc Lung Dis"},{"key":"2023072508224228600_B52"},{"key":"2023072508224228600_B53","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.93.20.11008","article-title":"Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice","volume":"93","author":"Hirsch","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072508224228600_B54","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1084\/jem.187.9.1463","article-title":"Production of mice deficient in genes for interleukin (IL)-1\u03b1, IL-1\u03b2, IL-1\u03b1\/\u03b2, and IL-1 receptor antagonist shows that IL-1\u03b2 is crucial in turpentine-induced fever development and glucocorticoid secretion","volume":"187","author":"Horai","year":"1998","journal-title":"J Exp Med"},{"key":"2023072508224228600_B55","doi-asserted-by":"crossref","first-page":"30517","DOI":"10.1074\/jbc.271.48.30517","article-title":"AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1","volume":"271","author":"Akeson","year":"1996","journal-title":"J Biol Chem"}],"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/189\/12\/1863\/1691352\/98-2173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/189\/12\/1863\/1691352\/98-2173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T09:32:49Z","timestamp":1690277569000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/189\/12\/1863\/25595\/Influence-of-Polymorphism-in-the-Genes-for-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,21]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1999,6,21]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.189.12.1863","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6,21]]}}}