{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:20:08Z","timestamp":1791127208581,"version":"4.1.0"},"reference-count":43,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,1,18]]},"abstract":"<jats:p>We studied the role of bone marrow B cell production in the renewal of peripheral B cells and the feedback mechanisms that control the entry of newly formed B cells into the peripheral B cell pools. When resting lymph node B cells are injected into B cell\u2013deficient hosts, a fraction of the transferred cells expands and constitutes a highly selected population that survives for prolonged periods of time by continuous cell renewal at the periphery. Although the number of donor B cells recovered is low, a significant fraction shows an activated phenotype, and the serum immunoglobulin (Ig)M levels are as in normal mice. This population of activated B cells is resistant to replacement by a new cohort of B cells and is able to feedback regulate both the entry of newly formed B cells into the peripheral pool and terminal differentiation. These findings suggest that peripheral B cell selection follows the first come, first served rule and that IgM-secreting cells are generated from a pool of stable activated B cells with an independent homeostasis.<\/jats:p>","DOI":"10.1084\/jem.189.2.319","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"319-330","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":85,"title":["Transfer of Small Resting B Cells into Immunodeficient Hosts Results in the Selection of a Self-renewing Activated B Cell Population"],"prefix":"10.1084","volume":"189","author":[{"given":"Fabien","family":"Agen\u00e8s","sequence":"first","affiliation":[{"name":"From the Laboratoire des Dynamiques Lymphocytaires, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 1961, Institut Pasteur, 75724 Paris, cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio A.","family":"Freitas","sequence":"additional","affiliation":[{"name":"From the Laboratoire des Dynamiques Lymphocytaires, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 1961, Institut Pasteur, 75724 Paris, cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1999,1,18]]},"reference":[{"key":"2023072508353029500_B1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1986.tb01482.x","article-title":"Lymphocyte population kinetics in the mouse","volume":"91","author":"Freitas","year":"1986","journal-title":"Immunol Rev"},{"key":"2023072508353029500_B2","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.4049\/jimmunol.131.6.2635","article-title":"Pre-B cells in mouse bone marrow: immunofluorescence stathmokinetic studies of the proliferation of cytoplasmic mu chain\u2013bearing cells in normal mice","volume":"131","author":"Opstelten","year":"1983","journal-title":"J Immunol"},{"key":"2023072508353029500_B3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-065X.1986.tb01504.x","article-title":"Population dynamics of bone marrow B lymphocytes","volume":"93","author":"Osmond","year":"1986","journal-title":"Immunol Rev"},{"key":"2023072508353029500_B4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/intimm\/1.4.321","article-title":"Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse","volume":"1","author":"Forster","year":"1989","journal-title":"Int Immunol"},{"key":"2023072508353029500_B5","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/eji.1830200812","article-title":"Accumulation of bromodeoxyuridine- labeled cells in central and peripheral lymphoid organs: minimal estimates of production and turnover rates of mature lymphocytes","volume":"20","author":"Rocha","year":"1990","journal-title":"Eur J Immunol"},{"key":"2023072508353029500_B6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0167-5699(93)90322-C","article-title":"The turnover of B-cell populations","volume":"14","author":"Osmond","year":"1993","journal-title":"Immunol Today"},{"key":"2023072508353029500_B7","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1002\/eji.1830270731","article-title":"Independent homeostatic regulation of B cell compartments","volume":"27","author":"Agen\u00e8s","year":"1997","journal-title":"Eur J Immunol"},{"key":"2023072508353029500_B8","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4049\/jimmunol.157.2.598","article-title":"Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A\/WySnJ mouse","volume":"157","author":"Lentz","year":"1996","journal-title":"J Immunol"},{"key":"2023072508353029500_B9","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/eji.1830250636","article-title":"The role of cellular competition in B cell survival and selection of B cell repertoires","volume":"25","author":"Freitas","year":"1995","journal-title":"Eur J Immunol"},{"key":"2023072508353029500_B10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/intimm\/1.3.237","article-title":"Lymphocyte population kinetics during the development of the immune system. 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