{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:30:28Z","timestamp":1791293428643,"version":"4.1.0"},"reference-count":53,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,2,1]]},"abstract":"<jats:p>Secondary lymphoid organ chemokine (SLC) is expressed in high endothelial venules and in T cell zones of spleen and lymph nodes (LNs) and strongly attracts naive T cells. In mice homozygous for the paucity of lymph node T cell (plt) mutation, naive T cells fail to home to LNs or the lymphoid regions of spleen. Here we demonstrate that expression of SLC is undetectable in plt mice. In addition to the defect in T cell homing, we demonstrate that dendritic cells (DCs) fail to accumulate in spleen and LN T cell zones of plt mice. DC migration to LNs after contact sensitization is also substantially reduced. The physiologic significance of these abnormalities in plt mice is indicated by a markedly increased sensitivity to infection with murine hepatitis virus. The plt mutation maps to the SLC locus; however, the sequence of SLC introns and exons in plt mice is normal. These findings suggest that the abnormalities in plt mice are due to a genetic defect in the expression of SLC and that SLC mediates the entry of naive T cells and antigen-stimulated DCs into the T cell zones of secondary lymphoid organs.<\/jats:p>","DOI":"10.1084\/jem.189.3.451","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"451-460","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":802,"title":["Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization"],"prefix":"10.1084","volume":"189","author":[{"given":"Michael D.","family":"Gunn","sequence":"first","affiliation":[{"name":"From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the \u2021Center for Experimental Medicine and \u00a7Laboratory Animal Research Center, Institute of Medical Science, University of \u2009Tokyo, Tokyo 108-8639, Japan; and the \u2016Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kyuwa","sequence":"additional","affiliation":[{"name":"From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the \u2021Center for Experimental Medicine and \u00a7Laboratory Animal Research Center, Institute of Medical Science, University of \u2009Tokyo, Tokyo 108-8639, Japan; and the \u2016Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Tam","sequence":"additional","affiliation":[{"name":"From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the \u2021Center for Experimental Medicine and \u00a7Laboratory Animal Research Center, Institute of Medical Science, University of \u2009Tokyo, Tokyo 108-8639, Japan; and the \u2016Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terutaka","family":"Kakiuchi","sequence":"additional","affiliation":[{"name":"From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the \u2021Center for Experimental Medicine and \u00a7Laboratory Animal Research Center, Institute of Medical Science, University of \u2009Tokyo, Tokyo 108-8639, Japan; and the \u2016Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Matsuzawa","sequence":"additional","affiliation":[{"name":"From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the \u2021Center for Experimental Medicine and \u00a7Laboratory Animal Research Center, Institute of Medical Science, University of \u2009Tokyo, Tokyo 108-8639, Japan; and the \u2016Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis T.","family":"Williams","sequence":"additional","affiliation":[{"name":"From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the \u2021Center for Experimental Medicine and \u00a7Laboratory Animal Research Center, Institute of Medical Science, University of \u2009Tokyo, Tokyo 108-8639, Japan; and the \u2016Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Nakano","sequence":"additional","affiliation":[{"name":"From the *Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143; the \u2021Center for Experimental Medicine and \u00a7Laboratory Animal Research Center, Institute of Medical Science, University of \u2009Tokyo, Tokyo 108-8639, Japan; 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