{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:43:30Z","timestamp":1779342210611,"version":"3.51.4"},"reference-count":55,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,2,1]]},"abstract":"<jats:p>Recently, results obtained from mice with targeted inactivations of postreplication DNA mismatch repair (MMR) genes have been interpreted to demonstrate a direct role for MMR in antibody variable (V) gene hypermutation. Here we show that mice that do not express the MMR factor Msh2 have wide-ranging defects in antigen-driven B cell responses. These include lack of progression of the germinal center (GC) reaction associated with increased intra-GC apoptosis, severely diminished antigen-specific immunoglobulin G responses, and near absence of anamnestic responses. Mice heterozygous for the Msh2 deficiency display an \u201cintermediate\u201d phenotype in these regards, suggesting that normal levels of Msh2 expression are critical for the B cell response. Interpretation of the impact of an MMR deficiency on the mechanism of V gene somatic hypermutation could be easily confounded by these perturbations.<\/jats:p>","DOI":"10.1084\/jem.189.3.471","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:54Z","timestamp":1027702134000},"page":"471-482","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice"],"prefix":"10.1084","volume":"189","author":[{"given":"Kalpit A.","family":"Vora","sequence":"first","affiliation":[{"name":"From the Department of Microbiology and Immunology and The Kimmel Cancer Institute, \u2009Jefferson Medical College, Philadelphia, Pennsylvania 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Tumas-Brundage","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Immunology and The Kimmel Cancer Institute, \u2009Jefferson Medical College, Philadelphia, Pennsylvania 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky M.","family":"Lentz","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Immunology and The Kimmel Cancer Institute, \u2009Jefferson Medical College, Philadelphia, Pennsylvania 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Cranston","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Immunology and The Kimmel Cancer Institute, \u2009Jefferson Medical College, Philadelphia, Pennsylvania 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Fishel","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Immunology and The Kimmel Cancer Institute, \u2009Jefferson Medical College, Philadelphia, Pennsylvania 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