{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:50:34Z","timestamp":1770475834463,"version":"3.49.0"},"reference-count":34,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,2,1]]},"abstract":"<jats:p>Two models have been proposed for the molecular mechanism by which the Tal1 oncogene causes T cell acute lymphoblastic leukemia (T-ALL). The activation model suggests that Tal1 as heterodimers with the E2A transcription factor activates the expression of oncogenes. The inhibition model postulates that Tal1 interferes with the tumor-suppressing function of E2A. In the Jurkat T cell line, originally derived from a patient with T-ALL, Tal1 is complexed with E2A proteins and the transcriptional activity of E2A is very low. When E2A activity was restored by expressing an E2A\u2013Tal1 fusion protein, E-T\/2, the Jurkat cells underwent growth arrest and subsequently apoptosis, thus supporting the inhibition model and suggesting that E2A loss may contribute to leukemic progression.<\/jats:p>","DOI":"10.1084\/jem.189.3.501","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"501-508","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Growth Inhibition and Apoptosis Due to Restoration of E2A Activity in T Cell Acute Lymphoblastic Leukemia Cells"],"prefix":"10.1084","volume":"189","author":[{"given":"Steven T.","family":"Park","sequence":"first","affiliation":[{"name":"From the *Department of Cell Biology and the \u2021Department of Cell Biology and Kaplan Cancer Center, New York University Medical Center, New York 10016; and the \u00a7Department of Molecular Pharmacology and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garry P.","family":"Nolan","sequence":"additional","affiliation":[{"name":"From the *Department of Cell Biology and the \u2021Department of Cell Biology and Kaplan Cancer Center, New York University Medical Center, New York 10016; and the \u00a7Department of Molecular Pharmacology and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Hong","family":"Sun","sequence":"additional","affiliation":[{"name":"From the *Department of Cell Biology and the \u2021Department of Cell Biology and Kaplan Cancer Center, New York University Medical Center, New York 10016; and the \u00a7Department of Molecular Pharmacology and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1999,2,1]]},"reference":[{"key":"2023072508321694400_B1","doi-asserted-by":"crossref","first-page":"10128","DOI":"10.1073\/pnas.86.24.10128","article-title":"The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif","volume":"86","author":"Begley","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072508321694400_B2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/j.1460-2075.1990.tb08126.x","article-title":"The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein","volume":"9","author":"Chen","year":"1990","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"2023072508321694400_B3","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1002\/j.1460-2075.1990.tb07535.x","article-title":"Site-specific recombination of the tal-1 gene is a common occurrence in human cell leukemia","volume":"9","author":"Brown","year":"1990","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"2023072508321694400_B4","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1182\/blood.V76.6.1220.1220","article-title":"The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study","volume":"76","author":"Carroll","year":"1990","journal-title":"Blood"},{"key":"2023072508321694400_B5","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1182\/blood.V86.2.666.bloodjournal862666","article-title":"Does activation of the TAL gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? 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