{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T22:28:46Z","timestamp":1699655326078},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1914,5,1]]},"abstract":"<jats:p>1. Sera from which the protective lipoids (unsaturated fatty acids) have been removed are toxic for the homologous animal.<\/jats:p>\n               <jats:p>2. The toxicity is due to three factors: (a) an alteration in the mechanism of coagulation, with resulting intravascular coagulation; (b) the exposure of the native serum proteins; (c) the formation of toxic split products (primary proteoses) by autolysis.<\/jats:p>\n               <jats:p>3. A definite maximum of toxicity can be determined, with a final stage of atoxicity due to continued autolysis.<\/jats:p>\n               <jats:p>4. Hirudin and sodium citrate do not protect animals.<\/jats:p>\n               <jats:p>5. Heating to 70\u00b0 C. destroys, or greatly lessens, the toxicity of the serotoxin, although the isolated proteoses are toxic after boiling.<\/jats:p>\n               <jats:p>6. The return of the extracted lipoids (saponified) neutralizes the toxicity.<\/jats:p>\n               <jats:p>7. Unsaturated soaps also neutralize the toxicity.<\/jats:p>\n               <jats:p>8. Sublethal doses produce extreme prostration, marked fall in body temperature, no eosinophilia, and an increase of antitrypsin.<\/jats:p>\n               <jats:p>9. Sublethal doses of rapidly prepared chloroform sera cause a decrease in coagulation time; sublethal doses of autolyzed sera cause an increase in coagulation time.<\/jats:p>\n               <jats:p>10. Previously injected animals are more resistant (increased antiferments).<\/jats:p>\n               <jats:p>11. Iodized animals are less resistant (decreased antiferments).<\/jats:p>","DOI":"10.1084\/jem.19.5.480","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T22:31:16Z","timestamp":1087511476000},"page":"480-500","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["SEROTOXIN"],"prefix":"10.1084","volume":"19","author":[{"given":"James W.","family":"Jobling","sequence":"first","affiliation":[{"name":"From the Department of Pathology of the College of Physicians and Surgeons, Columbia University, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Petersen","sequence":"additional","affiliation":[{"name":"From the Department of Pathology of the College of Physicians and Surgeons, Columbia University, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1914,5,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/19\/5\/480\/1125787\/480.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/19\/5\/480\/1125787\/480.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T06:57:54Z","timestamp":1601708274000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/19\/5\/480\/8043\/SEROTOXIN-STUDIES-ON-FERMENT-ACTION-XIV"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1914,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1914,5,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.19.5.480","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1914,5,1]]}}}