{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:13:30Z","timestamp":1789809210593,"version":"4.0.1"},"reference-count":43,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:p>T cell recruitment to extralymphoid tissues is fundamental to the initiation and perpetuation of the inflammatory state during immune and autoimmune responses. Interleukin (IL)-15 is a proinflammatory cytokine whose described functions largely overlap with those of IL-2. The latter is attributable in large part to its binding of the heterotrimeric receptor that contains the \u03b2 and \u03b3 chains of the IL-2R in combination with an unique IL-15R\u03b1 chain. However, unlike IL-2, IL-15 and its receptor have a wide tissue and cell type distribution, including endothelial cells. Here, we examine the effect of IL-15 on hyaluronan expression by endothelial cells, and investigate its role in vivo in promoting the extravasation of antigen-activated T cells through a CD44-dependent pathway. The expression of hyaluronan on primary endothelial cells and microvascular endothelial cell lines is induced by IL-15, whereas IL-2 has no such activity. Moreover, intraperitoneal administration of IL-15 or TNF-\u03b1 in the absence of other exogenous proinflammatory stimuli allows the extravasation of superantigen-stimulated T cells into this site in vivo in a CD44-dependent manner. T cell recruitment induced by IL-15 requires expression of an intact IL-2R\u03b2 chain, indicating that IL-15 operates in this context through the traditional IL-15R. The results suggest that IL-15 can regulate endothelial cell function and thereby enables a CD44-initiated adhesion pathway that facilitates entry of activated T lymphocytes into inflammatory sites. They further demonstrate a novel role for IL-15 (distinct from any of IL-2) in regulating microvascular endothelial cell adhesive function, help to understand the role of IL-15R expression on endothelium, and further support a central position for this cytokine in orchestrating multiple sequential aspects of T cell effector function and therefore chronic inflammatory processes.<\/jats:p>","DOI":"10.1084\/jem.190.1.9","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"9-20","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Interleukin 15 Induces Endothelial Hyaluronan Expression in Vitro and Promotes Activated T Cell Extravasation through a Cd44-Dependent Pathway in Vivo"],"prefix":"10.1084","volume":"190","author":[{"given":"Pila","family":"Estess","sequence":"first","affiliation":[{"name":"aFrom the Laboratory of Molecular Pathology, Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas 75235-9072"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Animesh","family":"Nandi","sequence":"additional","affiliation":[{"name":"aFrom the Laboratory of Molecular Pathology, Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas 75235-9072"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Mohamadzadeh","sequence":"additional","affiliation":[{"name":"aFrom the Laboratory of Molecular Pathology, Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas 75235-9072"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Siegelman","sequence":"additional","affiliation":[{"name":"aFrom the Laboratory of Molecular Pathology, Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas 75235-9072"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1999,7,5]]},"reference":[{"key":"2023072508473829100_R1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1084\/jem.183.3.1119","article-title":"CD44 and its ligand hyaluronate mediate rolling under physiologic flowa novel lymphocyte\/endothelial cell primary adhesion pathway","volume":"183","author":"DeGrendele","year":"1996","journal-title":"J. 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