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This revealed a biphasic infection, with an early phase of lytic replication accompanied and followed by sustained latency. Ultraviolet irradiation of the inoculum abolished all DNA- and mRNA-derived signals, and infection was inhibited by ganciclovir. Viral gene expression was most abundant in CD19+ B lymphocytes, suggesting that this model faithfully mimics the natural tropism of this virus. Short-term coinfection with HIV-1 did not alter the course of KSHV replication, nor did KSHV alter levels of HIV-1 p24 during the acute phase of the infection. Although no disease was evident in infected animals, SCID-hu Thy\/Liv mice should allow the detailed study of KSHV tropism, latency, and drug susceptibility.<\/jats:p>","DOI":"10.1084\/jem.190.12.1857","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1857-1868","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":96,"title":["Experimental Transmission of Kaposi's Sarcoma\u2013Associated Herpesvirus (Kshv\/Hhv-8) to Scid-Hu Thy\/Liv Mice"],"prefix":"10.1084","volume":"190","author":[{"given":"D.","family":"Dittmer","sequence":"first","affiliation":[{"name":"bDepartment of Microbiology and Immunology and Department of Medicine, University of California, San Francisco, California 94143"},{"name":"cHoward Hughes Medical Institute, University of California, San Francisco, California 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Stoddart","sequence":"additional","affiliation":[{"name":"aDepartments of Microbiology and Medicine, University of California, San Francisco, California 94143"},{"name":"dGladstone Institute of Virology and Immunology, San Francisco, California 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Renne","sequence":"additional","affiliation":[{"name":"bDepartment of Microbiology and Immunology and Department of Medicine, University of California, San Francisco, California 94143"},{"name":"cHoward Hughes Medical Institute, University of California, San Francisco, California 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Linquist-Stepps","sequence":"additional","affiliation":[{"name":"aDepartments of Microbiology and Medicine, University of California, San Francisco, California 94143"},{"name":"dGladstone Institute of Virology and Immunology, San Francisco, California 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"Moreno","sequence":"additional","affiliation":[{"name":"aDepartments of Microbiology and Medicine, University of California, San Francisco, California 94143"},{"name":"dGladstone Institute of Virology and Immunology, San Francisco, California 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bare","sequence":"additional","affiliation":[{"name":"aDepartments of Microbiology and Medicine, University of California, San Francisco, California 94143"},{"name":"dGladstone Institute of Virology and Immunology, San Francisco, California 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"McCune","sequence":"additional","affiliation":[{"name":"aDepartments of Microbiology and Medicine, University of California, San Francisco, California 94143"},{"name":"dGladstone Institute of Virology and Immunology, San Francisco, California 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ganem","sequence":"additional","affiliation":[{"name":"bDepartment of Microbiology and Immunology and Department of Medicine, University of California, San Francisco, California 94143"},{"name":"cHoward Hughes Medical Institute, University of California, San Francisco, California 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1999,12,20]]},"reference":[{"key":"2023072508475333900_R1","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1126\/science.7997879","article-title":"Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma","volume":"266","author":"Chang","year":"1994","journal-title":"Science."},{"key":"2023072508475333900_R2","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1056\/NEJM199505043321802","article-title":"Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas","volume":"332","author":"Cesarman","year":"1995","journal-title":"N. 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